Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Action potential-evoked Na+ influx are similar in axon and soma (Fleidervish et al. 2010)
Download zip file
Help downloading and running models
"In cortical pyramidal neurons, the axon initial segment (AIS) is pivotal in synaptic integration. It has been asserted that this is because there is a high density of Na+ channels in the AIS. However, we found that action potential-associated Na+ flux, as measured by high-speed fluorescence Na+ imaging, was about threefold larger in the rat AIS than in the soma. Spike-evoked Na+ flux in the AIS and the first node of Ranvier was similar and was eightfold lower in basal dendrites. ... In computer simulations, these data were consistent with the known features of action potential generation in these neurons."
Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) Na+ imaging reveals little difference in action potential-evoked Na+ influx between axon and soma.
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Fleidervish, Ilya [ilya.fleidervish at gmail.com];
for information about:
Neocortex L5/6 pyramidal GLU cell
Neocortex L2/3 pyramidal GLU cell
File not selected
<- Select file from this column.
Load Model Views
Fig 4B 100APs
Fig 4B 10APs
Loading data, please wait...