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Action potential-evoked Na+ influx are similar in axon and soma (Fleidervish et al. 2010)
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Model Information
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Accession:
136715
"In cortical pyramidal neurons, the axon initial segment (AIS) is pivotal in synaptic integration. It has been asserted that this is because there is a high density of Na+ channels in the AIS. However, we found that action potential-associated Na+ flux, as measured by high-speed fluorescence Na+ imaging, was about threefold larger in the rat AIS than in the soma. Spike-evoked Na+ flux in the AIS and the first node of Ranvier was similar and was eightfold lower in basal dendrites. ... In computer simulations, these data were consistent with the known features of action potential generation in these neurons."
Reference:
1 .
Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) Na+ imaging reveals little difference in action potential-evoked Na+ influx between axon and soma.
Nat Neurosci
13
:852-60
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Neocortex;
Cell Type(s):
Neocortex L5/6 pyramidal GLU cell;
Neocortex L2/3 pyramidal GLU cell;
Channel(s):
I Na,t;
I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Simplified Models;
Active Dendrites;
Action Potentials;
Implementer(s):
Fleidervish, Ilya [ilya.fleidervish at gmail.com];
Search NeuronDB
for information about:
Neocortex L5/6 pyramidal GLU cell
;
Neocortex L2/3 pyramidal GLU cell
;
I Na,t
;
I K
;
/
FleidervishEtAl2010
MechanismsVer7.1
readme.txt
Fig3A.ses
Fig4B 100APs ver7a.ses
Fig4B 10APs ver7a.ses
Fig6B.ses
init.hoc
mosinit.hoc
variable_dt.ses
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