ModelDB: Effect of trp-like current on APs during exposure to sinusoidal voltage (Chen et al. 2010)

Effect of trp-like current on APs during exposure to sinusoidal voltage (Chen et al. 2010)

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Citations

Accession:137263

"... Previous work showed that magnetic electrical field-induced antinoceptive action is mediated by activation of capsaicin-sensitive sensory afferents. In this study, a modified Hodgkin-Huxley model, in which TRP-like current (I-TRP) was incorporated, was implemented to predict the firing behavior of action potentials (APs), as the model neuron was exposed to sinusoidal changes in externally-applied voltage. ... Our simulation results suggest that modulation of TRP-like channels functionally expressed in small-diameter peripheral sensory neurons should be an important mechanism through which it can contribute to the firing pattern of APs."
Reference:
1 . Chen BS, Lo YC, Lius YC, Wu SN (2010) Effects of transient receptor potential-like current on the firing pattern of action potentials in the Hodgkin-Huxley neuron during exposure to sinusoidal external voltage. Chin J Physiol 53:423-9 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Axon;
Brain Region(s)/Organism:
Cell Type(s):	Squid axon;
Channel(s):	I trp;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	XPP;
Model Concept(s):	Simplified Models; Tutorial/Teaching; Action Potentials;
Implementer(s):	Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];

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