Interacting synaptic conductances during, distorting, voltage clamp (Poleg-Polsky and Diamond 2011)

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Accession:139150
This simulation examines the accuracy of the voltage clamp technique in detecting the excitatory and the inhibitory components of the synaptic drive.
Reference:
1 . Poleg-Polsky A, Diamond JS (2011) Imperfect Space Clamp Permits Electrotonic Interactions between Inhibitory and Excitatory Synaptic Conductances, Distorting Voltage Clamp Recordings. PLoS ONE 6(4):e119463-.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I N; I K;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Influence of Dendritic Geometry; Detailed Neuronal Models; Synaptic Integration;
Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I N; I K; Gaba; Glutamate;
{load_file("nrngui.hoc")}
objectvar save_window_, rvp_
objectvar scene_vector_[6]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin PointProcessGroupManager
{
load_file("pointgrp.hoc")
}
{
ocbox_ = new PointProcessGroupManager(0)
}
{object_push(ocbox_)}
{
ms = new MechanismStandard("IClamp")
ms.set("del", 0, 0)
ms.set("dur", 0, 0)
ms.set("amp", 0, 0)
mnews("IClamp", ms)
select(0)
execute("soma ocbox_.move(0.5)")
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessGroupManager", 686, 468, 538.2, 313.2)
}
objref ocbox_
//End PointProcessGroupManager

{
xpanel("RunControl", 0)
v_init = -60
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 0
xvalue("t","t", 2 )
tstop = 500
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.05
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 10
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
screen_update_invl = 0.05
xvalue("Scrn update invl","screen_update_invl", 1,"", 0, 1 )
realtime = 0
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(0,150)
}
{
xpanel("forall Ra=global_ra", 0)
global_ra = 99
xvalue("global Ra","global_ra", 1,"set_ra()", 1, 1 )
xpanel(1086,0)
}
{
save_window_ = new Graph(0)
save_window_.size(0,500,-80,40)
scene_vector_[4] = save_window_
{save_window_.view(0, -80, 500, 120, 1099, 99, 200.7, 100.9)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("soma.v(.5)", 1, 1, 0.8, 0.9, 2)
save_window_.addexpr("dend[0].v(.5)", 3, 1, 0.8, 0.9, 2)
save_window_.addexpr("dend[2].v(.5)", 2, 1, 0.8, 0.9, 2)
}
objectvar scene_vector_[1]
{doNotify()}

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