Interacting synaptic conductances during, distorting, voltage clamp (Poleg-Polsky and Diamond 2011)

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Accession:139150
This simulation examines the accuracy of the voltage clamp technique in detecting the excitatory and the inhibitory components of the synaptic drive.
Reference:
1 . Poleg-Polsky A, Diamond JS (2011) Imperfect Space Clamp Permits Electrotonic Interactions between Inhibitory and Excitatory Synaptic Conductances, Distorting Voltage Clamp Recordings. PLoS ONE 6(4):e119463-.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I N; I K;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Influence of Dendritic Geometry; Detailed Neuronal Models; Synaptic Integration;
Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I N; I K; Gaba; Glutamate;
COMMENT
//****************************//
// Created by Alon Polsky 	//
//    apmega@yahoo.com		//
//		2009			//
//****************************//
ENDCOMMENT

TITLE Shunting inhibition

NEURON {
	POINT_PROCESS shunt
	
	NONSPECIFIC_CURRENT ishunt

	RANGE e ,gmax,local_v,ishunt
	RANGE del,dur
	RANGE gshunt
}

UNITS {
	(nA) 	= (nanoamp)
	(mV)	= (millivolt)
	(nS) 	= (nanomho)
	(mM)    = (milli/liter)


}

PARAMETER {
	gmax=1	(nS)
	e= -70.0	(mV)
	dt (ms)
	v		(mV)
	del=0	(ms)
	dur=100 (ms)
}

ASSIGNED { 
	ishunt		(nA)  
	local_v	(mV):local voltage
}
STATE {
	gshunt

}

INITIAL {
      gshunt=0 

}    

BREAKPOINT {  
    
	IF(at_time(del)){
		state_discontinuity( gshunt, gmax)
	}
	IF(at_time(del+dur)){
		state_discontinuity( gshunt, 0)
	}	

	ishunt= (1e-3)*gshunt* (v- e)
	local_v=v
}








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