Single neuron with ion concentrations to model anoxic depolarization (Zandt et al. 2011)

 Download zip file 
Help downloading and running models
Accession:139266
A minimal single neuron model, including changing ion concentrations and homeostasis mechanisms. It shows the sudden depolarization that occurs after prolonged anoxia/ischemia.
Reference:
1 . Zandt BJ, ten Haken B, van Dijk JG, van Putten MJ (2011) Neural dynamics during anoxia and the "wave of death". PLoS One 6:e22127 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hodgkin-Huxley neuron;
Channel(s): I Na,t; I K; I K,leak; Na/K pump; I Cl, leak; I Na, leak;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Anoxic depolarization;
Implementer(s): Zandt, Bas-Jan [Bas-Jan.Zandt at biomed.uib.no];
Search NeuronDB for information about:  I Na,t; I K; I K,leak; Na/K pump; I Cl, leak; I Na, leak;
 
/
ZandtEtAl2011
readme.html
mainmodel.m
runmodel.m
screenshot.png
screenshot2.png
                            
File not selected

<- Select file from this column.
Loading data, please wait...