Hippocampus CA1: Simulations of LTP signaling pathways (Kim M et al. 2011)

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Accession:139655
This is a multi-compartmental, stochastic version of the Kim et al. 2010 paper. There are a few additional reactions, and some of the rate constants have been updated. It addresses the role of molecule anchoring in PKA dependent hippocampal LTP.
Reference:
1 . Kim M, Park AJ, Havekes R, Chay A, Guercio LA, Oliveira RF, Abel T, Blackwell KT (2011) Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. PLoS Comput Biol 7:e1002084 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): Dopaminergic Receptor; IP3;
Gene(s):
Transmitter(s): Dopamine;
Simulation Environment: NeuroRD;
Model Concept(s): Long-term Synaptic Plasticity; Signaling pathways;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; Dopaminergic Receptor; IP3; Dopamine;

Kim M, Park AJ, Havekes R, Chay A, Guercio LA, Oliveira RF, Abel T, Blackwell KT (2011) Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. PLoS Comput Biol 7:e1002084[PubMed]

References and models cited by this paper

References and models that cite this paper

Bhalla US (2017) Synaptic input sequence discrimination on behavioral time-scales mediated by reaction-diffusion chemistry in dendrites. Elife [Journal] [PubMed]

  • Discrimination on behavioral time-scales mediated by reaction-diffusion in dendrites (Bhalla 2017) [Model]

Chay A, Zamparo I, Koschinski A, Zaccolo M, Blackwell KT (2016) Control of betaAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons PLoS Computational Biology 12(2):e1004735 [Journal] [PubMed]

  • CA1 pyramidal cell receptor dependent cAMP dynamics (Chay et al. 2016) [Model]

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