Hyperconnectivity, slow synapses in PFC mental retardation and autism model (Testa-Silva et al 2011)

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Accession:140033
The subdirectory 'matlab' contains MATLAB scripts (The Mathworks, USA) that can be used to reproduce the panels of Figures 4-5. This directory contains files to reproduce sample computer simulations presented in the 2011 paper authored by Meredith, R., Testa-Silva, G., Loebel, A., Giugliano, M., de Kock, C.; Mansvelder, H. "Hyperconnectivity and slow synapses in prefrontal cortex of a model for mental retardation and autism". ABSTRACT "... We propose that these findings are tightly linked: using a network model, we show that slower synapses are essential to counterbalance hyperconnectivity in order to maintain a dynamic range of excitatory activity. However, the slow synaptic time constants induce decreased responsiveness to low frequency stimulation, which may explain deficits in integration and information processing in attentional neuronal networks in neurodevelopmental disorders."
Reference:
1 . Testa-Silva G, Loebel A, Giugliano M, de Kock CP, Mansvelder HD, Meredith RM (2012) Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism. Cereb Cortex 22:1333-42 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Synapse; Neural mass;
Brain Region(s)/Organism: Neocortex; Prefrontal cortex (PFC);
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Oscillations; Short-term Synaptic Plasticity; Attractor Neural Network;
Implementer(s): Giugliano, Michele [mgiugliano at gmail.com]; Loebel, Alex [alex.loebel at gmail.com];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic GLU cell;
 
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ModelDB_June2011
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