CA3 Radiatum/Lacunosum-Moleculare interneuron, Ih (Anderson et al. 2011)

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Accession:140732
"The present study examines the biophysical properties and functional implications of Ih in hippocampal area CA3 interneurons with somata in strata radiatum and lacunosum-moleculare.... The functional consequences of Ih were examined with regard to temporal summation and impedance measurements. ... From impedance measurements, we found that Ih did not confer theta-band resonance, but flattened the impedance–frequency relations instead. ... Finally, a model of Ih was employed in computational analyses to confirm and elaborate upon the contributions of Ih to impedance and temporal summation."
Reference:
1 . Anderson WD, Galvan EJ, Mauna JC, Thiels E, Barrionuevo G (2011) Properties and functional implications of Ih in hippocampal area CA3 interneurons Pflugers Arch. 462:895-912 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Hippocampus CA3 stratum radiatum lacunosum-moleculare interneuron;
Channel(s): I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s):
Implementer(s):
Search NeuronDB for information about:  I h;
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Fig6
Fig6A and S6
Fig7
readme.txt
                            
Properties and Functional Implications of Ih in Hippocampal Area CA3 Interneurons
Anderson et al., 2011, Pflugars Archives

The folders contain sample code for the simulations underlying Fig 6, Fig 7 and Fig S6. 

* For Fig 6, open the corresponding folder and execute Fig6BC.m. Functions will be called 
to generate voltage traces, impedance curves, and phase plots identical to those in panels 
B and C.

* For Fig 7, execute Fig7ACD.m to generate the traces shown in panels A, Ca, and Cb.

* Finally, we included code for simulated voltage-clamp of our Ih model (Fig 6A, and Fig S6). 
Execute VClamp_Activation.m to generate a family of curves showing h-current responses to the 
voltage-clamp protocol for activation of gh (Fig 1C).


Queries can be directed to Warren Anderson at warrena@temple.edu

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