Multiscale interactions between chemical and electric signaling in LTP (Bhalla 2011)

 Download zip file 
Help downloading and running models
Accession:141226
"Synaptic plasticity leads to long-term changes in excitability, whereas cellular homeostasis maintains excitability. Both these processes involve interactions between molecular events, electrical events, and network activity. Here I explore these intersections with a multilevel model that embeds molecular events following synaptic calcium influx into a multicompartmental electrical model of a CA1 hippocampal neuron. ..."
Reference:
1 . Bhalla US (2011) Multiscale interactions between chemical and electric signaling in LTP induction, LTP reversal and dendritic excitability. Neural Netw 24:943-9 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS;
Model Concept(s): Synaptic Plasticity; Long-term Synaptic Plasticity; Multiscale; Homeostasis;
Implementer(s): Bhalla, Upinder S [bhalla at ncbs.res.in];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; I Na,t; I A; I K; I K,Ca; I_AHP;
// genesis
// cell parameter file for the 1991 Traub CA1 hippocampal cell
// "phi" parameter reduced by e-3
*cartesian
*relative
*symmetric

*set_global RM 1.0	//ohm*m^2
*set_global RA 1.0	//ohm*m
*set_global CM 0.03     //F/m^2
*set_global EREST_ACT	-0.06	// volts

// The format for each compartment parameter line is :
// name  parent  x       y       z       d       ch      dens ...
// For channels, "dens" =  maximum conductance per unit area of compartment

/* NOTE: The format of the cell descriptor files does not allow for
   continuation to another line.  The following long line lists the
   soma channels with their "density" parameters.

   Ca_conc	-17.402e12
	Not really a channel, but a "Ca_concen" object.  Normally, the B 
	field is set to "dens"/compt_volume (m^3), but the negative sign
	causes the absolute value to be used with no scaling by volume.
   Na		300  
   Ca		 40
   K_DR		150
   K_AHP	  8
   K_C		100
   K_A		 50
*/

basal_3  none    0   220  0  3.84 Ca_conc 8.96e-3 Ca 50 K_AHP 8 K_C 50
basal_5  .    0   220  0  3.84 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50
basal_6  .    0   220  0  3.84 Ca_conc 8.96e-3 Na 200 Ca 120 K_DR 200 K_AHP 8 K_C 100
basal_8  .	    0   110  0  3.84 Ca_conc -34.53e12 Na 150 Ca 80 K_DR 100 K_AHP 8 K_C 200

soma	basal_8    0  125  0  8.46 Ca_conc -17.402e12 Na 300 Ca 40 K_DR 250 K_AHP 8 K_C 100 K_A 50


apical_10 	soma  0  120  0  4.0 Ca_conc -26.404e12 Na 150 Ca 80 K_DR 100 K_AHP 8 K_C 200   glu 700 NMDA 200
apical_11  apical_10  0   120  0  3 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 80 K_DR 60 K_A 100  glu 700 NMDA 200
apical_12	apical_11  0   120  0  3 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 60 K_DR 60 K_A 100 glu 700 NMDA 200
apical_13  	apical_12  0   120  0  2.6 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 50 K_DR 60 K_A 100   glu 700 NMDA 200
apical_14  	apical_13  0   120  0  2.6 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100   glu 700 NMDA 200
apical_15	apical_14  0   120  0  2.6 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100   glu 700 NMDA 200
apical_16	apical_15  0   120  0  2.6 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100   glu 700 NMDA 200
apical_17	apical_16  0   120  0  2.6 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100   glu 700 NMDA 200
apical_18	apical_17  0   120  0  2.6 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100   glu 700 NMDA 200
apical_19 apical_18	   0  120   0  2.6

lat_11_1  apical_10  -60   60  0  2 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 80 K_DR 60 K_A 100  glu 700 NMDA 200
lat_11_2  	lat_11_1  -60   60  0  1.8 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100   glu 700 NMDA 200
lat_11_3  	lat_11_2  0   80  0  1.5 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200
lat_11_4  	lat_11_3  0   80  0  1.5 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200

lat_13_1	apical_12  40   40  0  1.0 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200
lat_13_2	lat_13_1  40   40  0  1.0 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200

lat_14_1	lat_13_2  0   10  0  1.0 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200
lat_14_2  	.  0   10  0  1.0 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200
lat_14_3  	.  0   70  0  1.0 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200
lat_14_10  	.  0   30  0  1.0 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200
lat_15_1  	.  0   60  0  1.0 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200
lat_15_2  	.  0   60  0  1.0 Ca_conc 8.96e-3 Ca 70 K_AHP 8 K_C 50 Na 40 K_DR 60 K_A 100 glu 700 NMDA 200

spine_neck_14_1	lat_14_1	0.5  0  0  0.1
spine_head_14_1	.  		0.5  0  0  0.5 NMDA_Ca_conc 8.96e-3 glu 700 Ca_NMDA 20 NMDA 200 Ca 60
spine_neck_14_2	lat_14_2	0.5  0  0  0.1
spine_head_14_2	.  		0.5  0  0  0.5 NMDA_Ca_conc 8.96e-3 glu 700 Ca_NMDA 20 NMDA 200 Ca 60
spine_neck_14_10	lat_14_10	0.5  0  0  0.1
spine_head_14_10	.  		0.5  0  0  0.5 NMDA_Ca_conc 8.96e-3 glu 700 Ca_NMDA 20 NMDA 200 Ca 60

Loading data, please wait...