Engaging distinct oscillatory neocortical circuits (Vierling-Claassen et al. 2010)

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Accession:141273
"Selective optogenetic drive of fast-spiking (FS) interneurons (INs) leads to enhanced local field potential (LFP) power across the traditional “gamma” frequency band (20–80 Hz; Cardin et al., 2009). In contrast, drive to regular-spiking (RS) pyramidal cells enhances power at lower frequencies, with a peak at 8 Hz. The first result is consistent with previous computational studies emphasizing the role of FS and the time constant of GABAA synaptic inhibition in gamma rhythmicity. However, the same theoretical models do not typically predict low-frequency LFP enhancement with RS drive. To develop hypotheses as to how the same network can support these contrasting behaviors, we constructed a biophysically principled network model of primary somatosensory neocortex containing FS, RS, and low-threshold spiking (LTS) INs. ..."
Reference:
1 . Vierling-Claassen D, Cardin JA, Moore CI, Jones SR (2010) Computational modeling of distinct neocortical oscillations driven by cell-type selective optogenetic drive: separable resonant circuits controlled by low-threshold spiking and fast-spiking interneurons. Front Hum Neurosci 4:198 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 pyramidal intratelencephalic L2-6 cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s): I Na,t; I T low threshold; I K; I M; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Detailed Neuronal Models; Brain Rhythms; Evoked LFP; Touch;
Implementer(s): Vierling-Claassen, Dorea ;
Search NeuronDB for information about:  Neocortex V1 pyramidal intratelencephalic L2-6 cell; I Na,t; I T low threshold; I K; I M; I h; I K,Ca; I Calcium;
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Vierling-ClaassenEtAl2010
batchsims
confiles
README
ar.mod
ca.mod *
cad.mod *
cat.mod
fdsexp2syn.mod *
Gfluct.mod *
gnetstim.mod
kca.mod *
km.mod *
kv.mod *
na_2.mod
light_batch_FSdrive.hoc
light_genconn_DB.m
lightgamma_drive_DB.hoc
lightgamma_init_DB.hoc
lightgamma_LFP_DB.hoc
lightgamma_localconn_DB.hoc
lightgamma_network_DB.hoc
lightgamma_noise_DB.hoc
lightgamma_wiring_DB.hoc
lightgamma_wiring_proc_DB.hoc
                            
README

This is the readme for code in support of the paper:

Front Hum Neurosci. 2010 Nov 22;4:198. Computational modeling of
distinct neocortical oscillations driven by cell-type selective
optogenetic drive: separable resonant circuits controlled by
low-threshold spiking and fast-spiking interneurons. Vierling-Claassen
D, Cardin JA, Moore CI, Jones SR.

Code was generated using NEURON Version 6.1

Primary author of code was Dorea Vierling-Claassen (contact at
dorea@brown.edu), in consultation with Mike Sikora, based on previous
models by Stephanie R. Jones (2007 and 2009, also available on Model
DB)

TO RUN:

Compile folder using mknrndll, then run the file light_batch_FSdrive,
which generates 11 separate files, each containing 600 ms simulation,
for baseline and 10 drive frequencies in the modeled case of light
drive to fast-spiking (FS) cells case (files are saved in folder
titled "batchsims")

FILE INFORMATION:

lightgamma_init_DB.hoc is called by light_batch_FSdrive and loads all
relevant processes from the following files:

1) lightgamma_network_DB.hoc defines cell morphology, intrinsic
currents and synaptic dynamics for each cell type

2) lightgamma_wiring_DB.hoc contains processes for wiring between
populations and depends on files controlling random connectivity in
confiles folder, connectivity is fixed for all runs. Connectivity
files were generated in matlab using light_genconn_DB.m, also
included. Connectivity files included here are exactly as in the
published work.

3) lightgamma_wiring_proc_DB.hoc includes processes for light drive

4) lightgamma_localconn_DB.hoc sets network connectivity

5) lightgamma_drive_DB.hoc sets light drive to either FS or RS cells,
to run the RS case, will need to comment out FS drive and comment in
RS drive in this file

6) lightgamma_noise_DB.hoc adds background noise, based on a
modification of noise from Destexhe et al 2001, also available on
model DB

7) lightgamma_LFP_DB.hoc contains process to generate average voltage
over all pyramidal cells, which was the bases for subsequent signal
processing

** This code runs the FS case, to run the case of RS drive, define new
filenames in light_batch_FS, comment out the FS drive and comment in
the RS drive in lightgamma_drive_DB**

Many thanks to other contributers to model DB's whose .mod files are
included here. Credits are in individual files and additional
citations are in the published work.

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Last updated 9-22-2011, Dorea V-C

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