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Biophysically detailed model of the mouse sino-atrial node cell (Kharche et al. 2011)
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This model is developed to study the role of various electrophysiological mechanisms in generating cardiac pacemaking action potentials (APs).The model incorporates membrane ionic currents and intracellular mechanisms contributing to spontaneous mouse SAN APs. The model was validated by testing the functional roles of individual membrane currents in one and multiple parameter analyses.The roles of intracellular Ca2+-handling mechanisms on cardiac pacemaking were also investigated in the model.
Kharche S, Yu J, Lei M, Zhang H (2011) A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases.
Am J Physiol Heart Circ Physiol
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Neuron or other electrically excitable cell;
Cardiac atrial cell;
C or C++ program;
Action Potential Initiation;
Kharche, Sanjay ;
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