Effects of the membrane AHP on the Lateral Superior Olive (LSO) (Zhou & Colburn 2010)

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Accession:143114
This simulation study investigated how membrane afterhyperpolarization (AHP) influences spiking activity of neurons in the Lateral Superior Olive (LSO). The model incorporates a general integrate-and-fire spiking mechanism with a first-order adaptation channel. Simulations focus on differentiating the effects of GAHP, tauAHP, and input strength on (1) spike interval statistics, such as negative serial correlation and chopper onset, and (2) neural sensitivity to interaural level difference (ILD) of LSO neurons. The model simulated electrophysiological data collected in cat LSO (Tsuchitani and Johnson, 1985).
Reference:
1 . Zhou Y, Colburn HS (2010) A modeling study of the effects of membrane afterhyperpolarization on spike interval statistics and on ILD encoding in the lateral superior olive. J Neurophysiol 103:2355-71 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Auditory brainstem;
Cell Type(s): Lateral Superior Olive (LSO) cell; Abstract integrate-and-fire leaky neuron;
Channel(s): I_AHP;
Gap Junctions:
Receptor(s): GabaA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Action Potential Initiation; Simplified Models; Spike Frequency Adaptation; Depolarization block; Audition;
Implementer(s): Zhou, Yi [yizhou at bu.edu];
Search NeuronDB for information about:  GabaA; Glutamate; I_AHP;
: relative refractory period for a nonlinear IF cell
: implemented as a high conductance
: Usage is to have a one of the NetCon's watching the cell voltage
: send an event with 0 delay to this object

NEURON {
	POINT_PROCESS Refrac_rel
	RANGE gr, e,  g, tau
	NONSPECIFIC_CURRENT i
}

UNITS {
	(nA) = (nanoamp)
	(mV) = (millivolt)
	(umho) = (micromho)
}

PARAMETER {
	tau=1 (ms)   : the decay 
	gr = 1 (umho) : conductance during refractory period
	e = -65 (mV) : refractory channel reversal potential
}

ASSIGNED {
	
	v (mV)
	i (nA)
}

STATE {
	g (umho)
}


INITIAL {
	g = 0 : not in refractory period
}


BREAKPOINT {
	SOLVE state METHOD cnexp
	i = g*(v - e)
}

DERIVATIVE state {
	g' = -g/tau
}


NET_RECEIVE(w) { : w not used. external event is for entering refractory period
	if (flag == 0) { : external event
		g = g+gr   
	}
}


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