CA1 pyramidal neurons: effects of Kv7 (M-) channels on synaptic integration (Shah et al. 2011)

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Accession:144392
NEURON mod files from the paper: Shah et al., 2011. In this study, using a combination of electrophysiology and computational modelling, we show that these channels selectively influence peri-somatic but not dendritic post-synaptic excitatory synaptic potential (EPSP) integration in CA1 pyramidal cells. This may be important for their relative contributions to physiological processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy.
Reference:
1 . Shah MM, Migliore M, Brown DA (2011) Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons. J Physiol 589:6029-38 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I M; I h; I_AHP;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; I Na,t; I A; I K; I M; I h; I_AHP; Glutamate;
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modeldb
readme.txt
cacumm.mod *
cat.mod *
h.mod *
kadist.mod *
KahpM95.mod *
kaprox.mod *
kdrca1.mod *
km.mod *
na3n.mod *
naxn.mod *
fig-3c.hoc
fixnseg.hoc *
geo9068802.hoc *
mosinit.hoc
                            
NEURON mod files from the paper:
Mala M. Shah, Michele Migliore, and David A.
Brown,
Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat
hippocampal pyramidal neurons. J Physiol. 2011 589:6029-38.

In this study, using a combination of electrophysiology
and computational modelling, we show that these channels selectively influence
peri-somatic but not dendritic post-synaptic excitatory synaptic potential (EPSP) integration in
CA1 pyramidal cells. This may be important for their relative contributions to physiological
processes such as synaptic plasticity as well as patho-physiological conditions such as epilepsy.
The fig-3c.hoc reproduces the traces shown in Fig.3c of the paper.


Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui fig-3c.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
fig-3c.hoc 
will open the simulation window.

Questions on how to use this model
should be directed to michele.migliore@cnr.it




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