Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
ModelDB related resources
Computational neuroscience ecosystem
Models in mercurial repository
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Download zip file
Help downloading and running models
The hippocampus in well known for its role in learning and memory processes. The CA1 region is the output of the hippocampal formation and pyramidal neurons in this region are the elementary units responsible for the processing and transfer of information to the cortex. Using this detailed single neuron model, it is investigated the conditions under which individual CA1 pyramidal neurons process incoming information in a complex (non-linear) as opposed to a passive (linear) manner. This detailed compartmental model of a CA1 pyramidal neuron is based on one described previously (Poirazi, 2003). The model was adapted to five different reconstructed morphologies for this study, and slightly modified to fit the experimental data of (Losonczy, 2006), and to incorporate evidence in pyramidal neurons for the non-saturation of NMDA receptor-mediated conductances by single glutamate pulses. We first replicate the main findings of (Losonczy, 2006), including the very brief window for nonlinear integration using single-pulse stimuli. We then show that double-pulse stimuli increase a CA1 pyramidal neuron’s tolerance for input asynchrony by at last an order of magnitude. Therefore, it is shown using this model, that the time window for nonlinear integration is extended by more than an order of magnitude when inputs are short bursts as opposed to single spikes.
Gomez Gonzalez JF, Mel BW, Poirazi P (2012) Distinguishing Linear vs. Non-Linear Integration in CA1 Radial Oblique Dendrites: It's about Time.
Front Comput Neurosci.
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal cell;
Detailed Neuronal Models;
for information about:
Hippocampus CA1 pyramidal cell
File not selected
<- Select file from this column.
Loading data, please wait...
Questions, comments, problems? Email the
How to cite ModelDB
© This site is Copyright 2018 Shepherd Lab, Yale University