Hypocretin and Locus Coeruleus model neurons (Carter et al 2012)

 Download zip file 
Help downloading and running models
Accession:145162
Conductance based model of the hypocretin neurons (HCRT) and another one of the Locus Coeruleus one (LC). The HCRT drive the LCs via the HCRT receptor on the LCs. The LCs lead to the awakening of the mice if the number of spikes raises over 10 spikes in 10 seconds window.
Reference:
1 . Carter ME, Brill J, Bonnavion P, Huguenard JR, Huerta R, de Lecea, L (2012) Mechanism for Hypocretin-mediated sleep-to-wake transitions PNAS
Model Information (Click on a link to find other models with that property)
Model Type: Axon; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Locus Coeruleus neuron;
Channel(s): I Na,t; I T low threshold; I A; I K; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s):
Implementer(s): Huerta, Ramon [rhuerta at ucsd.edu];
Search NeuronDB for information about:  I Na,t; I T low threshold; I A; I K; I K,Ca; I Calcium;
This is the readme associated with the model for the paper:

Carter ME, Brill J, Bonnavion P, Huguenard JR, Huerta R, de Lecea, L (2012)
Mechanism for Hypocretin-mediated sleep-to-wake transitions PNAS

Please see the HOWTOINSTALL file for installation on a linux (ubuntu) platform.

These model files were supplied by Ramon Huerta.

Loading data, please wait...