A generic MAPK cascade model for random parameter sampling analysis (Mai and Liu 2013)

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Accession:146024
A generic three-tier MAPK cascade model constructed by comparing previous MAPK models covering a range of biosystems. Pseudo parameters and random sampling were employed for qualitative analysis. A range of kinetic behaviors of MAPK activation, including ultrasensitivity, bistability, transient activation and oscillation, were successfully reproduced in this generic model. The mechanisms were revealed by statistic analysis of the parameter sets.
Reference:
1 . Mai Z, Liu H (2013) Random parameter sampling of a generic three-tier MAPK cascade model reveals major factors affecting its versatile dynamics PLoS ONE 8(1):e54441
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Methods;
Implementer(s):
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mapk
readme.txt
iniCons_turn.txt
iniP_turn.txt
models.m
                            
This is the readme for the model associated with the publication:

Mai Z, Liu H (2013) Random Parameter Sampling of a Generic Three-Tier
MAPK Cascade Model Reveals Major Factors Affecting Its Versatile
Dynamics. PLoS ONE 8(1): e54441. doi:10.1371/journal.pone.0054441

The models.m file is a matlab program.

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