Resonance properties through Chirp stimulus responses (Narayanan Johnston 2007, 2008)

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Accession:147539
...we constructed a simple, single-compartment model with Ih as the only active current... we found that both resonance frequency and resonance strength increased monotonically with the increase in the h conductance, supporting the notion of a direct, graded relationship between h conductance and resonance properties... (Narayanan and Johnston, 2007). ...we show that the h channels introduce an apparent negative delay in the local voltage response of these neurons with respect to the injected current within the theta frequency range... we found that the total inductive phase increased monotonically with the h conductance, whereas it had a bell-shaped dependence on both the membrane voltage and the half-maximal activation voltage for the h conductance. (Narayanan and Johnston, 2008).
References:
1 . Narayanan R, Johnston D (2007) Long-term potentiation in rat hippocampal neurons is accompanied by spatially widespread changes in intrinsic oscillatory dynamics and excitability. Neuron 56:1061-75 [PubMed]
2 . Narayanan R, Johnston D (2008) The h channel mediates location dependence and plasticity of intrinsic phase response in rat hippocampal neurons. J Neurosci 28:5846-60 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Conductance distributions;
Implementer(s): Narayanan, Rishikesh [rishi at mbu.iisc.ernet.in];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; I h;
This directory contains NEURON files associated with computing
neuronal response to a Chirp stimulus. These files, and the functions
there in, could be used to generate traces that shed light on the
sensitivity of impedance measurements (both amplitude- and
phase-related) to various parameters associated with the h channel
and passive properties of a single compartmental model. These files
will help recreate results presented in Fig. 7 of the 2007 paper
and in Fig. 3 of the 2008 paper, both referenced below.

Rishikesh Narayanan and Daniel Johnston, “Long-term potentiation
in rat hippocampal neurons is accompanied by spatially widespread
changes in intrinsic oscillatory dynamics and excitability,” Neuron,
56(6), pp.  1061–1075, December 2007.

Rishikesh Narayanan and Daniel Johnston, “The h channel mediates
location dependence and plasticity of intrinsic phase response in
rat hippocampal neurons,” The Journal of Neuroscience, 28(22), pp.
5846–5860, May 2008.

An example output voltage file, named "ChirpGh_10.00.txt", is saved
in the Output directory.  It corresponds to default values for all
other parameters, with the h conductance set at 100 uS/cm2.  This
was generated using the "Chirp_Gh()" function.  The corresponding
current values are in the file "ChirpI.txt". Both files contain
1002000 points, corresponding to a time period of 25050 ms, with
40 points per ms. If impedance analyses were to be performed with
values in the "ChirpGh_10.00.txt" file as the voltage response, and
values in the file "ChirpI.txt" as the current input, then the
measurements should read as follows:

Resonance frequency (f_R): 6.77 Hz 
Resonance strength (Q): 1.338
Maximal impedance amplitude (|Z|_Max): 50.9 MOhm 
Total inductive area (Phi_L): 0.0545 rad.Hz

For details about each of these measurements, refer to the two
papers mentioned above.

Written by Rishikesh Narayanan. Contact: rishi.n@gmail.com

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