Circadian clock model in mammals (PK/PD model) (Kim & Forger 2013)

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Accession:148320
A systems pharmacology model of the mammalian circadian clock including PF-670462 (CK1d/e inhibitor).
Reference:
1 . Kim JK, Forger DB, Marconi M, Wood D, Doran A, Wager T, Chang C, Walton KM (2013) Modeling and validating chronic pharmacological manipulation of circadian rhythms CPT: Pharmacometrics & Systems Pharmacology 2(7):1-11
Model Information (Click on a link to find other models with that property)
Model Type: Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Suprachiasmatic nucleus (SCN) neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: Mathematica;
Model Concept(s): Therapeutics; Phase Response Curves; Circadian Rhythms;
Implementer(s): Kim, Jae Kyoung [kimjack0 at kaist.ac.kr];
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modeldb
README.txt
PF-670462_Model.nb
                            
This is a systems pharmacology model of the mammalian circadian clock
including PF-670462 developed in the paper:

Jae Kyoung Kim, Daniel B Forger, Michael Marconi, Douglas Wood, Angela
Doran, Travis Wager, Cheng Chang, and Kevin M Walton (2013) "Modeling
and validating chronic pharmacological manipulation of circadian
rhythms", CPT: Pharmacometrics & Systems Pharmacology.

The model is available in the format of Mathematica.

This model is largely based on the detailed model of the mammalian
circadian clock in the paper:

Jae Kyoung Kim and Daniel B. Forger (2012) "A mechanism for robust
circadian timekeeping via balanced stoichiometry", Molecular Systems
Biology

The original model is available from the ModelDB (Access code:
145801).

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