Rescue of plasticity by a computationally predicted protocol (Liu et al. 2013)

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Accession:149162
" ... A computational model, which simulated molecular processes underlying long-term synaptic facilitation (LTF) induction, predicted a rescue protocol of five pulses of 5-HT at non-uniform interstimulus intervals that overcame the consequences of reduced CREB-binding protein (CBP) and restored LTF. ..."
Reference:
1 . Liu RY, Zhang Y, Baxter DA, Smolen P, Cleary LJ, Byrne JH (2013) Deficit in Long-Term Synaptic Plasticity Is Rescued by a Computationally Predicted Stimulus Protocol J. Neurosci. 33:6944-6949
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Aplysia;
Cell Type(s): Aplysia sensory neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Signaling pathways;
Implementer(s): Zhang, Yili [Yili.Zhang at uth.tmc.edu];
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LiuEtAl2013
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LiuEtAl2013.ode
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