Synaptic gating at axonal branches, and sharp-wave ripples with replay (Vladimirov et al. 2013)

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Accession:150446
The computational model of in vivo sharp-wave ripples with place cell replay. Excitatory post-synaptic potentials at dendrites gate antidromic spikes arriving from the axonal collateral, and thus determine when the soma and the main axon fire. The model allows synchronous replay of pyramidal cells during sharp-wave ripple event, and the replay is possible in both forward and reverse directions.
Reference:
1 . Vladimirov N, Tu Y, Traub RD (2013) Synaptic gating at axonal branches, and sharp-wave ripples with replay: a simulation study. Eur J Neurosci 38:3435-47 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon; Dendrite; Connectionist Network;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell;
Channel(s): I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium; I Potassium; I_AHP;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Oscillations; Synchronization; Axonal Action Potentials; Place cell/field; Conduction failure; Brain Rhythms;
Implementer(s): Vladimirov, Nikita ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; AMPA; I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium; I Potassium; I_AHP; Gaba; Glutamate;
TITLE Calcium dynamics in a submembrane shell

COMMENT
  from paper "A branching dendritic model of a rodent CA3 pyramidal neurone." Traub RD et al. J Physiol. (1994) 
  implemented by Nikita Vladimirov <nikita.vladimirov@gmail.com>
ENDCOMMENT

NEURON {
	SUFFIX Cad
	USEION ca READ ica WRITE cai
	RANGE  phi, beta
}

UNITS {
	(mA)	= (milliamp)
 	(molar) = (1/liter)			: moles do not appear in units
 	(mM)	= (millimolar)
}

PARAMETER {
	phi	 	
	beta 	(/ms)
}

STATE {	cai (mM) }

INITIAL { 
	cai = 0
}

ASSIGNED { 
	ica		(mA/cm2) 
}

BREAKPOINT {
	SOLVE state METHOD cnexp
	if( cai < 0 ){ cai = 0 }
}

DERIVATIVE state { 
	cai' = - phi * ica - beta * (cai)
}

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