Synaptic gating at axonal branches, and sharp-wave ripples with replay (Vladimirov et al. 2013)

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Accession:150446
The computational model of in vivo sharp-wave ripples with place cell replay. Excitatory post-synaptic potentials at dendrites gate antidromic spikes arriving from the axonal collateral, and thus determine when the soma and the main axon fire. The model allows synchronous replay of pyramidal cells during sharp-wave ripple event, and the replay is possible in both forward and reverse directions.
Reference:
1 . Vladimirov N, Tu Y, Traub RD (2013) Synaptic gating at axonal branches, and sharp-wave ripples with replay: a simulation study. Eur J Neurosci 38:3435-47 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon; Dendrite; Connectionist Network;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell;
Channel(s): I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium; I Potassium; I_AHP;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Oscillations; Synchronization; Axonal Action Potentials; Place cell/field; Conduction failure; Brain Rhythms;
Implementer(s): Vladimirov, Nikita ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; AMPA; I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium; I Potassium; I_AHP; Gaba; Glutamate;
    COMMENT
      ipulse3.mod
      Generates a current pulse when it receives an input event.
      User specifies dur (pulse duration) and amp (pulse amplitude).
      Ignores events that arrive during an ongoing pulse.
      version 1.0 NTC
	  author: Ted Carnevale
    ENDCOMMENT

    NEURON {
      POINT_PROCESS Ipulse3
      RANGE dur, amp, i
      ELECTRODE_CURRENT i
    }

    UNITS {
      (nA) = (nanoamp)
    }

    PARAMETER {
      dur (ms) <0, 1e9> : duration of ON phase
      amp (nA) : how big
    }

    ASSIGNED {
      ival (nA)
      i (nA)
      on
    }

    INITIAL {
      on = 0
      i = 0
      ival = 0
    }

    BREAKPOINT {
      i = ival
    }

    NET_RECEIVE (w) {
      if (flag == 0) { : not a self event
        if (on == 0) {
          : turn it on
          ival = amp
          on = 1
          : prepare to turn it off
          net_send(dur, 1)
        }
      } else { : a self event
        : turn it off
        ival = 0
        on = 0
      }
    }

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