Stochastic calcium mechanisms cause dendritic calcium spike variability (Anwar et al. 2013)


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Accession:150635
" ... In single Purkinje cells, spontaneous and synaptically evoked dendritic calcium bursts come in a variety of shapes with a variable number of spikes. The mechanisms causing this variability have never been investigated thoroughly. In this study, a detailed computational model employing novel simulation routines is applied to identify the roles that stochastic ion channels, spatial arrangements of ion channels and stochastic intracellular calcium have towards producing calcium burst variability. … Our findings suggest that stochastic intracellular calcium mechanisms play a crucial role in dendritic calcium spike generation and are, therefore, an essential consideration in studies of neuronal excitability and plasticity."
Reference:
1 . Anwar H, Hepburn I, Nedelescu H, Chen W, De Schutter E (2013) Stochastic calcium mechanisms cause dendritic calcium spike variability J Neurosci 33(40):15848-15867 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje cell;
Channel(s): I Na,t; I T low threshold; I p,q; I K; I K,Ca; Ca pump;
Gap Junctions:
Receptor(s): AMPA;
Gene(s): Cav3.1 CACNA1G; Cav2.1 CACNA1A;
Transmitter(s):
Simulation Environment: STEPS (web link to model);
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Calcium dynamics;
Implementer(s): Anwar, Haroon [haroon.anwar at gmail.com]; Hepburn, Iain [ihepburn at oist.jp];
Search NeuronDB for information about:  Cerebellum Purkinje cell; AMPA; I Na,t; I T low threshold; I p,q; I K; I K,Ca; Ca pump;
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