In single Purkinje cells, spontaneous and synaptically evoked
dendritic calcium bursts come in a variety of shapes with a variable number of
The mechanisms causing this variability have never been investigated thoroughly.
In this study, a detailed computational model employing novel simulation routines is
applied to identify the roles that stochastic ion channels, spatial arrangements of ion
channels and stochastic intracellular calcium have towards producing calcium burst
Our findings suggest that stochastic intracellular calcium
mechanisms play a crucial role in dendritic calcium spike generation and are, therefore, an
essential consideration in studies of neuronal excitability and plasticity."
Anwar H, Hepburn I, Nedelescu H, Chen W, De Schutter E (2013) Stochastic calcium mechanisms cause dendritic calcium spike variability J Neurosci 33(40):15848-15867