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Excitatory synaptic interactions in pyramidal neuron dendrites (Behabadi et al. 2012)
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" ... We hypothesized that if two excitatory pathways bias their synaptic projections towards proximal vs. distal ends of the basal branches, the very different local spike thresholds and attenuation factors for inputs near and far from the soma might provide the basis for a classical-contextual functional asymmetry. Supporting this possibility, we found both in compartmental models and electrophysiological recordings in brain slices that the responses of basal dendrites to spatially separated inputs are indeed strongly asymmetric. ..."
Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW (2012) Location-dependent excitatory synaptic interactions in pyramidal neuron dendrites.
PLoS Comput Biol
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Neuron or other electrically excitable cell;
Neocortex L5/6 pyramidal GLU cell;
Dendritic Action Potentials;
Spatio-temporal Activity Patterns;
Detailed Neuronal Models;
Behabadi, Bardia [bardiafb+mdb at gmail.com];
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Neocortex L5/6 pyramidal GLU cell
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