Recurrent discharge in a reduced model of cat spinal motoneuron (Balbi et al, 2013)

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Following a distal stimulation of a motor fibre, only a fraction of spinal motoneurons are able to produce a re-excitation of the initial segment leading to an orthodromically conducted action potential, known as recurrent discharge. In order to show the reciprocal interplay of the axonal initial segment and the soma leading to recurrent discharge in detail, a reduced model of a cat spinal motoneuron was developed.
1 . Balbi P, Martinoia S, Colombo R, Massobrio P (2014) Modelling recurrent discharge in the spinal a-motoneuron: reappraisal of the F wave. Clin Neurophysiol 125:427-9 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Na,p; I Na,t; I K; I K,Ca;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Recurrent Discharge;
Implementer(s): Balbi, Pietro [piero.balbi at];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K; I K,Ca;
//moddir channels
xlabel("Click Init & Run to display an ortodromic action")
xlabel("potential. Insert IClamp[0] into a distal node (from interpreter:")
xlabel("node[35] IClamp[0].loc(.5), for example), and see whether antidromic")
xlabel("soma invasion occurs (you would also reduce the intensity of IClamp[0]")
xlabel("when stimulating at the nodes). Then change the soma.diam to 35 um and")
xlabel("to 39 um and see what happens. Also try changing various geometric and")
xlabel("biophysical parameters.")

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