Olfactory bulb juxtaglomerular models (Carey et al., 2015)

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Accession:152111
" ...We investigated how OB circuits shape inhalation-driven dynamics in MCs using a modeling approach that was highly constrained by experimental results. First, we constructed models of canonical OB circuits that included mono- and disynaptic feedforward excitation, recurrent inhibition and feedforward inhibition of the MC. We then used experimental data to drive inputs to the models and to tune parameters; inputs were derived from sensory neuron responses during natural odorant sampling (sniffing) in awake rats, and model output was compared to recordings of MC responses to odorants sampled with the same sniff waveforms. This approach allowed us to identify OB circuit features underlying the temporal transformation of sensory inputs into inhalation-linked patterns of MC spike output. ..."
Reference:
1 . Carey RM, Sherwood WE, Shipley MT, Borisyuk A, Wachowiak M (2015) Role of intraglomerular circuits in shaping temporally structured responses to naturalistic inhalation-driven sensory input to the olfactory bulb. J Neurophysiol 113:3112-29 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral cell; Olfactory receptor neuron; Olfactory bulb main interneuron periglomerular cell; Olfactory bulb main interneuron granule MC cell; Olfactory bulb main interneuron granule TC cell;
Channel(s):
Gap Junctions:
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Gene(s):
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Simulation Environment: MATLAB;
Model Concept(s): Olfaction;
Implementer(s):
Search NeuronDB for information about:  Olfactory bulb main mitral cell; Olfactory receptor neuron; Olfactory bulb main interneuron periglomerular cell; Olfactory bulb main interneuron granule MC cell; Olfactory bulb main interneuron granule TC cell;
 
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carey_2013
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