A model of local field potentials generated by medial superior olive neurons (Goldwyn et al 2014)

 Download zip file 
Help downloading and running models
Accession:152112
A computational model of local field potentials generated by medial superior olive neurons. These field potentials are known as the "auditory neurophonic". MSO neuron is modeled as a soma and two dendrites (following Mathews et al, Nature Neurosci, 2010). Intracellular and a 1D extracellular domain are dynamically coupled and solved to simulate spatial-temporal patterns of membrane voltage and extracellular voltage in response to trains of synaptic inputs (monolateral or bilateral, excitation and/or inhibition). The model produces spatio-temporal patterns similar to neurophonic responses recorded in vivo, as discussed in the accompanying manuscript.
Reference:
1 . Goldwyn JH, McLaughlin M, Verschooten E, Joris PX, Rinzel J (2014) A model of the medial superior olive explains spatiotemporal features of local field potentials J Neurosci. 34(35):11705-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Medial Superior Olive (MSO) cell;
Channel(s): I h; I_KLT;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Evoked LFP;
Implementer(s): Goldwyn, Joshua [jhgoldwyn at gmail.com];
Search NeuronDB for information about:  I h; I_KLT;
/
GoldwynEtAl2014
readme.txt
makeFig.m
MSO_dae.m
runNeurophonic.m
                            
readme.txt

Simulation code accompanying the manuscript:
"A model of the medial superior olive explains spatiotemporal features
of local field potentials"
By JH Goldwyn, M McLaughlin, E Verschooten, PX Joris, J Rinzel
Manuscript submitted to J Neuroscience 1/14/2014

Matlab (R2012b) simulation code written by JH Goldwyn and posted to
ModelDB on 1/14/2014

This code makes use of SUNDIALS (Suite of Nonlinear and Differential
Algebraic Equation Solvers) and its interface to Matlab (sundialsTB).

These can be downloaded at the website:

http://computation.llnl.gov/casc/sundials/main.html

Documentation and installation instructions for SUNDIALS and
sundialsTB are also available at that address.

Contents:
makeFig.m: An m-file that reproduces Figures 4, 8, and 11 from the
manuscript.

runNeurophonic.m: An m-file that produces 3D (surf command)
spatial-temporal profiles of membrane potential and extracellular
potential.  Parameter values in this file that can be modified by the
user include synaptic strength (gE, gI); frequency of synaptic events
(synFreq); dendrite receiving excitatory synaptic events (stimType);
length of simulation (tEnd); etc.

MSO_dae.m: A function file that defines and solves the system of
equations that model the membrane potential of a MSO neuron and
extracellular potential in the surrounding "virtual cylinder" of
extracellular space.  See manuscript for details. This function is
called by makeFig.m and runNeurophonic.m

Loading data, please wait...