We developed a biophysical model of the basal ganglia-corticothalamic
network in this work.
"... We demonstrate that the typical absence seizure activities can be
controlled and modulated by the direct GABAergic projections from the
substantia nigra pars reticulata (SNr) to either the thalamic
reticular nucleus (TRN) or the specific relay nuclei (SRN) of
thalamus, through different biophysical mechanisms.
... results highlight the bidirectional functional roles of
basal ganglia in controlling and modulating absence seizures, and
might provide novel insights into the therapeutic treatments of this
Chen M, Guo D, Wang T, Jing W, Xia Y, Xu P, Luo C, Valdes-Sosa PA, Yao D (2014) Bidirectional control of absence seizures by the Basal Ganglia: a computational evidence PLoS Computational Biology 10(3):e1003495 [PubMed]
Chen M, Guo D, Li M, Ma T, Wu S, Ma J, Cui Y, Xi Y (2015) Critical Roles of the Direct GABAergic Pallido-cortical Pathway in Controlling Absence Seizures PLoS Computational Biology 11(10):e1004539 [PubMed]