PreBotzinger Complex inspiratory neuron with NaP and CAN currents (Park and Rubin 2013)

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Accession:152292
We have built on earlier models to develop a single-compartment Hodgkin-Huxley type model incorporating NaP and CAN currents, both of which can play important roles in bursting of inspiratory neurons in the PreBotzinger Complex of the mammalian respiratory brain stem. The model tracks the evolution of membrane potential, related (in)activation variables, calcium concentration, and available fraction of IP3 channels. The model can produce several types of bursting, presented and analyzed from a dynamical systems perspective in our paper.
Reference:
1 . Park C, Rubin JE (2013) Cooperation of intrinsic bursting and calcium oscillations underlying activity patterns of model pre-Botzinger complex neurons. J Comput Neurosci 34:345-66 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Respiratory column neuron; PreBotzinger complex neuron;
Channel(s): I Na,p; I K; I CAN; I Sodium;
Gap Junctions:
Receptor(s): AMPA; IP3;
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Bursting;
Implementer(s): Rubin, Jonathan E [jonrubin at pitt.edu]; Park, Choongseok [cpark at ncat.edu];
Search NeuronDB for information about:  AMPA; IP3; I Na,p; I K; I CAN; I Sodium;
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