Single E-I oscillating network with amplitude modulation (Avella Gonzalez et al. 2012)

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"... Intriguingly, the amplitude of ongoing oscillations, such as measured in EEG recordings, fluctuates irregularly, with episodes of high amplitude (HAE) alternating with episodes of low amplitude (LAE). ... Here, we show that transitions between HAE and LAE in the alpha/beta frequency band occur in a generic neuronal network model consisting of interconnected inhibitory (I) and excitatory (E) cells that are externally driven by sustained depolarizing currents(cholinergic input) and trains of action potentials that activate excitatory synapses. In the model, action potentials onto inhibitory cells represent input from other brain areas and desynchronize network activity, being crucial for the emergence of amplitude fluctuations. ..."
1 . Avella Gonzalez OJ, van Aerde KI, van Elburg RA, Poil SS, Mansvelder HD, Linkenkaer-Hansen K, (2012) External drive to inhibitory cells induces alternating episodes of high- and low-amplitude oscillations. PLoS Comput Biol 8:e1002666-40 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Abstract single compartment conductance based cell;
Channel(s): I K; I Na, leak;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Simulation Environment: NEURON; MATLAB;
Model Concept(s):
Implementer(s): Avella G. Oscar Javier [oscarjavella at gmail dot com];
Search NeuronDB for information about:  GabaA; AMPA; I K; I Na, leak;
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