Vestibulo-Ocular Reflex model in Matlab (Clopath at al. 2014)

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" ... We then introduce a minimal model that consists of learning at the parallel fibers to Purkinje cells with the help of the climbing fibers. Although the minimal model reproduces the behavior of the wild-type animals and is analytically tractable, it fails at reproducing the behavior of mutant mice and the electrophysiology data. Therefore, we build a detailed model involving plasticity at the parallel fibers to Purkinje cells' synapse guided by climbing fibers, feedforward inhibition of Purkinje cells, and plasticity at the mossy fiber to vestibular nuclei neuron synapse. The detailed model reproduces both the behavioral and electrophysiological data of both the wild-type and mutant mice and allows for experimentally testable predictions. "
1 . Clopath C, Badura A, De Zeeuw CI, Brunel N (2014) A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. J Neurosci 34:7203-15 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum purkinje cell;
Gap Junctions:
Simulation Environment: MATLAB;
Model Concept(s): Synaptic Plasticity;
Implementer(s): Clopath, Claudia [c.clopath at];
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