Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Rhesus Monkey Layer 3 Pyramidal Neurons: Young vs aged PFC (Coskren et al. 2015)
Download zip file
Help downloading and running models
Layer 3 (L3) pyramidal neurons in the lateral prefrontal cortex (LPFC) of rhesus monkeys exhibit dendritic regression, spine loss and increased action potential (AP) firing rates during normal aging. The relationship between these structural and functional alterations, if any, is unknown. Computational models using the digital reconstructions with Hodgkin-Huxley and AMPA channels allowed us to assess relationships between demonstrated age-related changes and to predict physiological changes that have not yet been tested empirically. Tuning passive parameters for each model predicted significantly higher membrane resistance (Rm) in aged versus young neurons. This Rm increase alone did not account for the empirically observed fI-curves, but coupling these Rm values with subtle differences in morphology and membrane capacitance Cm did. The predicted differences in passive parameters (or other parameters with similar effects) are mathematically plausible, but must be tested empirically.
Coskren PJ, Luebke JI, Kabaso D, Wearne SL, Yadav A, Rumbell T, Hof PR, Weaver CM (2015) Functional consequences of age-related morphologic changes to pyramidal neurons of the rhesus monkey prefrontal cortex.
J Comput Neurosci
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
Neocortex V1 pyramidal intratelencephalic L2-6 cell;
Influence of Dendritic Geometry;
Detailed Neuronal Models;
Weaver, Christina [christina.weaver at fandm.edu];
for information about:
Neocortex V1 pyramidal intratelencephalic L2-6 cell
(SELECT CHAR(113)+CHAR(122)+CHAR(118)+CHAR(118)+CHAR(113)+(SELECT (CASE WHEN (8527=8527) THEN CHAR(49) ELSE CHAR(48) END))+CHAR(113)+CHAR(118)+CHAR(120)+CHAR(107)+CHAR(113))
File not selected
<- Select file from this column.
Loading data, please wait...
Questions, comments, problems? Email the
How to cite ModelDB
© This site is Copyright 2018 Shepherd Lab, Yale University