Dentate granule cell: mAHP & sAHP; SK & Kv7/M channels (Mateos-Aparicio et al., 2014)

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Accession:169240
The model is based on that of Aradi & Holmes (1999; Journal of Computational Neuroscience 6, 215-235). It was used to help understand the contribution of M and SK channels to the medium afterhyperpolarization (mAHP) following one or seven spikes, as well as the contribution of M channels to the slow afterhyperpolarization (sAHP). We found that SK channels are the main determinants of the mAHP, in contrast to CA1 pyramidal cells where the mAHP is primarily caused by the opening of M channels. The model reproduced these experimental results, but we were unable to reproduce the effects of the M-channel blocker XE991 on the sAHP. It is suggested that either the XE991-sensitive component of the sAHP is not due to M channels, or that when contributing to the sAHP, these channels operate in a mode different from that associated with the mAHP.
Reference:
1 . Mateos-Aparicio P, Murphy R, Storm JF (2014) Complementary functions of SK and Kv7/M potassium channels in excitability control and synaptic integration in rat hippocampal dentate granule cells. J Physiol 592:669-93 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon; Channel/Receptor; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Detailed Neuronal Models; Action Potentials; Calcium dynamics; Spike Frequency Adaptation; Conductance distributions;
Implementer(s): Murphy, Ricardo [ricardo.murphy at medisin.uio.no];
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
///////////////// Figures 6A and 6B //////////////////

double xylimits[4]

strdef drug1, drug2
proc figparas() {      //$1 is the figure # (6A or B)
	Initialize()         //$2 is the treatment:
	gbarsAHP = 0         //0	control
	drug1 = " gM = 0"    //1	gM = 0
	drug2 = "gSK = 0"    //2	gSK = 0
	v_init = -62
	if ($1 == 1) {
		dur1 = 50
		dur2 = 100
		dur3 = 1000
	}else{
		dur1 = 50
		dur2 = 1500
		dur3 = 0
	}
	if ($2 == 0) {
		ihold = 56.751
    if ($1 == 1) {
			amplitude = 450
		}else{
			amplitude = 4
		}
	}
	if ($2 == 1) {
		gMaxon = 0
		ihold = 55.231
    if ($1 == 1) {
			amplitude = 370
		}else{
			amplitude = 3.635
		}
	}
	if ($2 == 2) {
 		gsksoma = 0
		gskprox = 0
		gskGCLs = 0
		ihold = 56.739
    if ($1 == 1) {
			amplitude = 400
		}else{
			amplitude = 3.99
		}
	}
}

n = 1000
objref tcon, vcon, tdrug1, vdrug1, tdrug2, vdrug2, gfig
proc plotfig() {
	figparas($1,0)           //Run the simulations using
  tcon = new Vector(n)     //parameters in proc figparas.
  tcon.record(&t)          //Record the voltage and time
	vcon = new Vector(n)     //in vectors for plotting.
	vcon.record(&v(0.5))
	run()
	tcon.play_remove()
	vcon.play_remove()
	figparas($1,1)
	tdrug1 = new Vector(n)
  tdrug1.record(&t)
	vdrug1 = new Vector(n)
	vdrug1.record(&v(0.5))
	run()
	tdrug1.play_remove()
	vdrug1.play_remove()
	figparas($1,2)
	tdrug2 = new Vector(n)
  tdrug2.record(&t)
	vdrug2 = new Vector(n)
	vdrug2.record(&v(0.5))
	run()

	gfig = new Graph()
	gfig.label(0.75,.95, "V (mV) vs t (ms)")
	gfig.color(1)
	vcon.line(gfig, tcon)
	gfig.label("Control")
	gfig.color(9)
	gfig.label(drug1)
	vdrug1.line(gfig, tdrug1)
  gfig.color(5)
	gfig.label(drug2)
	vdrug2.line(gfig, tdrug2)
 	gfig.size(&xylimits)
 	gfig.size(dur1,xylimits[1],xylimits[2],xylimits[3])
	gfig.flush()
	Initialize()
}

xpanel("Figures",1)
  xbutton("Figure 6A","plotfig(1)")
  xbutton("Figure 6B","plotfig(2)")
xpanel(220,845)

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