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Discharge hysteresis in motoneurons (Powers & Heckman 2015)
 
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Model Information
Model File
Citations
Accession:
183949
"Motoneuron activity is strongly influenced by the activation of persistent inward currents (PICs) mediated by voltage-gated sodium and calcium channels. ... It has recently been suggested that a number of factors other than PIC can contribute to delta F (firing rate differences between motoneurons) values, including mechanisms underlying spike frequency adaptation and spike threshold accommodation. In the present study, we used a set of compartmental models representing a sample of 20 motoneurons with a range of thresholds to investigate how several different intrinsic motoneuron properties can potentially contribute to variations in F values. ... Our results indicate that, although other factors can contribute, variations in discharge hysteresis and delta F values primarily reflect the contribution of dendritic PICs to motoneuron activation.
Reference:
1 .
Powers RK, Heckman CJ (2015) Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings: a simulation study.
J Neurophysiol
114
:184-98
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s):
I Na,p;
I Na,t;
I L high threshold;
I K;
I M;
I K,Ca;
I_AHP;
I Calcium;
I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Kv1.2 KCNA2;
Kv1.9 Kv7.1 KCNQ1;
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Spike Frequency Adaptation;
Implementer(s):
Powers, Randy [rkpowers at u.washington.edu];
Search NeuronDB
for information about:
Spinal cord lumbar motor neuron alpha ACh cell
;
I Na,p
;
I Na,t
;
I L high threshold
;
I K
;
I M
;
I K,Ca
;
I Sodium
;
I Calcium
;
I_AHP
;
/
Discharge_hysteresis
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