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Discharge hysteresis in motoneurons (Powers & Heckman 2015)
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"Motoneuron activity is strongly influenced by the activation of persistent inward currents (PICs) mediated by voltage-gated sodium and calcium channels. ... It has recently been suggested that a number of factors other than PIC can contribute to delta F (firing rate differences between motoneurons) values, including mechanisms underlying spike frequency adaptation and spike threshold accommodation. In the present study, we used a set of compartmental models representing a sample of 20 motoneurons with a range of thresholds to investigate how several different intrinsic motoneuron properties can potentially contribute to variations in F values. ... Our results indicate that, although other factors can contribute, variations in discharge hysteresis and delta F values primarily reflect the contribution of dendritic PICs to motoneuron activation.
Powers RK, Heckman CJ (2015) Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings. A simulation study.
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Neuron or other electrically excitable cell;
Spinal cord L motor neuron alpha;
I L high threshold;
Kv1.9 Kv7.1 KCNQ1;
Spike Frequency Adaptation;
Powers, Randy [rkpowers at u.washington.edu];
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Spinal cord L motor neuron alpha
I L high threshold
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