Discharge hysteresis in motoneurons (Powers & Heckman 2015)

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Accession:183949
"Motoneuron activity is strongly influenced by the activation of persistent inward currents (PICs) mediated by voltage-gated sodium and calcium channels. ... It has recently been suggested that a number of factors other than PIC can contribute to delta F (firing rate differences between motoneurons) values, including mechanisms underlying spike frequency adaptation and spike threshold accommodation. In the present study, we used a set of compartmental models representing a sample of 20 motoneurons with a range of thresholds to investigate how several different intrinsic motoneuron properties can potentially contribute to variations in F values. ... Our results indicate that, although other factors can contribute, variations in discharge hysteresis and delta F values primarily reflect the contribution of dendritic PICs to motoneuron activation.
Reference:
1 . Powers RK, Heckman CJ (2015) Contribution of intrinsic motoneuron properties to discharge hysteresis and its estimation based on paired motor unit recordings. A simulation study. J Neurophysiol 114:184-198 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Spinal cord lumbar motor neuron alpha cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I K; I M; I K,Ca; I_AHP; I Calcium; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.2 KCNA2; Kv1.9 Kv7.1 KCNQ1;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Spike Frequency Adaptation;
Implementer(s): Powers, Randy [rkpowers at u.washington.edu];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha cell; I Na,p; I Na,t; I L high threshold; I K; I M; I K,Ca; I Sodium; I Calcium; I_AHP;
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Discharge_hysteresis
Model hoc files and output
README.txt
Gfluctdv.mod *
ghchan.mod *
kca2.mod *
KCNQ.mod *
kdrRL.mod *
km_hu.mod
kv1_gp.mod *
L_Ca.mod *
L_Ca_inact.mod *
mAHP.mod *
mAHPvt.mod
na3rp.mod *
naps.mod *
napsi.mod *
AHPlen.csv
FasterMis.csv
FR3cablepas.hoc
FRMot3dendNaHH.hoc
gramp.ses
HiDKCa.csv
init_3dend_gramp.hoc
LCai.csv
Napi.csv
pars2manyhocs.py *
ProxCa.csv
SetConductances2.hoc *
SlowM.csv
standard.csv
twobirampsdel.hoc *
                            
,,"ProxClt","ProxCaht",    //modified from standard to move L_Ca proximal; increased by 10% to get similar initial current in I-V curve
"soma","diam",45,65,
"soma","L",45,65,	       
"soma","g_pas",1.2500e-3,5.0000e-3,
"soma","e_pas",-72,-72,
"soma","gbar_na3rp",0.12,0.12,	
"soma","gbar_naps",0.00096,0.00096,	
"soma","sh_na3rp",9,9,			
"soma","sh_naps",19,19,			
"soma","ar_na3rp",1,1
"soma","ar_naps",1,1,
"soma","gMax_kdrRL",0.1,0.1,
"soma","gcamax_mAHP",0.8E-005,0.8E-005,		
"soma","gkcamax_mAHP",0.012,0.012,		
"soma","taur_mAHP",70,40,		
"soma","ghbar_gh",0.9E-004,1.75E-004,	
"soma","half_gh",-75,-75,
,,,,
"is","L",50,50,
"is","diam",4.5327,5.8666,
"is","g_pas",0.00100,0.00100,
"is","e_pas",-72,-72,
"is","gbar_na3rp",0.44,0.6,	
"is","gbar_naps",0.00704,0.0096,	
"is","sh_na3rp",1,1,		
"is","sh_naps",11,11,		
"is","ar_na3rp",1,1,
"is","ar_naps",1,1,
"is","gMax_kdrRL",0.4,0.4,
,,,,
"axonhillock","nseg",5,5,
"axonhillock","diam(0:1)","4.5327:13.32433","5.8666:19.998",
"axonhillock","g_pas",0.00100,0.00100,
"axonhillock","e_pas",-72,-72,
"axonhillock","gbar_na3rp",0.44,0.6,	
"axonhillock","gbar_naps",0.00704,0.0096,	
"axonhillock","sh_na3rp",1,1,		
"axonhillock","sh_naps",11,11,	
"axonhillock","ar_na3rp",1,1,
"axonhillock","ar_naps",1,1,
"axonhillock","gMax_kdrRL",0.4,0.4,
,,,,
"*","forsec dend{",,,
"Global","nseg",10,10,
"Global","L",4021.333,4992,
"Global","diam(0:0.2)","16.827:17.788","21.635:22.596",
"Global","diam(0.2:1)","17.788:0","22.596:0",
"Global","g_pas",5.0000e-5,1.0000e-4
"Global","e_pas",-72,-72,
"Global","gbar_na3rp",0.00075,0.00075,		
"Global","gbar_naps",1.2e-5,1.2e-5,		
"Global","sh_na3rp",9,9,				
"Global","sh_naps",19,19,			
"Global","ar_na3rp,1,1,
"Global","ar_naps,1,1,
"Global","gMax_kdrRL(0:0.04)","0.08:0.08","0.08:0.08",
"Global","gMax_kdrRL(0.04:1)","0.00033:0.00033","0.00033:0.00033",
"Global","gcabar_L_Ca",0,0	
"Global","g_kca2(0:0.3)","1.8e-4:1.8e-4","1.8e-4:1.8e-4",		
"Global","g_kca2(0.3:1)","0:0","0:0",
"Global","depth2_kca2",200,200,
"Global","taur2_kca2",120,120,
"Global","gcamax_mAHP(0:0.1)","0.8E-005:0.8E-005","0.8E-005:0.8E-005"
"Global","gcamax_mAHP(0.1:1)","0:0","0:0",
"Global","gkcamax_mAHP(0:0.1)","0.0012:0.0012","0.0012:0.0012", 	
"Global","gkcamax_mAHP(0.1:1)","0:0","0:0",
"Global","taur_mAHP",70,40,		//changed from 143
"Global","ghbar_gh",0.9e-4,1.75e-4,
"Global","half_gh",-75,-75,
"*","}",,,

"d1","gcabar_L_Ca(0:0.3)","1.1e-4:1.1e-4","1.1e-4:1.1e-4",	
"d2","gcabar_L_Ca(0:0.3)","1.54e-4:1.54e-4","1.54e-4:1.54e-4",	
"d3","gcabar_L_Ca(0:0.3)","2.09e-4:2.09e-4","2.09e-4:2.09e-4",	

,,,,
"Global","tmin_kdrRL",0.8,0.8,
"Global","taumax_kdrRL",20,20,
"Global","mVh_kdrRL",-21,-21,
"Global","mvhalfca_mAHP",-26,-26,
"Global","qinf_na3rp",4.8,4.8,
"Global","thinf_na3rp",-50.5,-50.5,
"Global","Rd_na3rp",0.06,0.06,
"Global","qd_na3rp",1.3,1.3,
"Global","qg_na3rp",1.3,1.3,
"Global","thi1_na3rp",-35,-35,
"Global","thi2_na3rp",-35,-35,
"Global","vslope_naps",5,5,
"Global","celsius",37,37,
"Global","theta_m_L_Ca",-40,-40,			
,
"Global","V0",-15,10,

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