We explore adaptation induced bursting as a mechanism for theta oscillations in hippocampal area CA1. To do this, we have developed a mean-field system for a network of fitted Izhikevich neurons with sparse coupling and heterogeneity. The code contained here runs the mean-field system pointwise or on a two-parameter mesh, in addition to networks of neurons that are smaller then those considered in the paper. The file README.pdf contains instructions on use.
Note that the following file (peakfinder):
http://www.mathworks.com/matlabcentral/fileexchange/25500-peakfinder-x0--sel--thresh--extrema--includeendpoints--interpolate-
is required to compute burst frequencies in the mean-field system and must be downloaded and placed in the same root folder as MFSIMULATOR.mat
Reference:
1 .
Ferguson KA, Njap F, Nicola W, Skinner FK, Campbell SA (2015) Examining the limits of cellular adaptation bursting mechanisms in biologically-based excitatory networks of the hippocampus. J Comput Neurosci 39:289-309 [PubMed]
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