Find models by
Find models for
Find models of
Electrical synapses (gap junctions)
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
Cell signaling/ion channel variability effects on neuronal response (Anderson, Makadia, et al. 2015)
Download zip file
Help downloading and running models
" ... We evaluated the impact of molecular variability in the expression of cell signaling components and ion channels on electrophysiological excitability and neuromodulation. We employed a computational approach that integrated neuropeptide receptor-mediated signaling with electrophysiology. We simulated a population of neurons in which expression levels of a neuropeptide receptor and multiple ion channels were simultaneously varied within a physiological range. We analyzed the effects of variation on the electrophysiological response to a neuropeptide stimulus. ..."
Anderson WD, Makadia HK, Vadigepalli R (2015) Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes.
J Comput Neurosci
(Click on a link to find other models with that property)
Neuron or other electrically excitable cell;
I L high threshold;
Spike Frequency Adaptation;
Makadia, Hirenkumar K [hiren.makadia at gmail.com];
Anderson, Warren D [warren.anderson at jefferson.edu];
Vadigepalli, Rajanikanth [Rajanikanth.Vadigepalli at jefferson.edu];
for information about:
I L high threshold
File not selected
<- Select file from this column.
Loading data, please wait...