Cell signaling/ion channel variability effects on neuronal response (Anderson, Makadia, et al. 2015)

 Download zip file 
Help downloading and running models
Accession:185300
" ... We evaluated the impact of molecular variability in the expression of cell signaling components and ion channels on electrophysiological excitability and neuromodulation. We employed a computational approach that integrated neuropeptide receptor-mediated signaling with electrophysiology. We simulated a population of neurons in which expression levels of a neuropeptide receptor and multiple ion channels were simultaneously varied within a physiological range. We analyzed the effects of variation on the electrophysiological response to a neuropeptide stimulus. ..."
Reference:
1 . Anderson WD, Makadia HK, Vadigepalli R (2015) Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes. J Comput Neurosci [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor; Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Brainstem neuron;
Channel(s): I L high threshold; I A; I K,Ca; I Sodium; I Potassium; Na/Ca exchanger; I_Na,Ca; I_KD;
Gap Junctions:
Receptor(s): AT1R;
Gene(s):
Transmitter(s): Angiotensin;
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Action Potentials; Signaling pathways; Spike Frequency Adaptation; Parameter sensitivity; Depolarization block; G-protein coupled; Conductance distributions; Bifurcation; Synaptic noise; Neuromodulation;
Implementer(s): Makadia, Hirenkumar K [hiren.makadia at gmail.com]; Anderson, Warren D [warren.anderson at jefferson.edu]; Vadigepalli, Rajanikanth [Rajanikanth.Vadigepalli at jefferson.edu];
Search NeuronDB for information about:  AT1R; I L high threshold; I A; I K,Ca; I Sodium; I Potassium; Na/Ca exchanger; I_Na,Ca; I_KD; Angiotensin;
function y0=LoadInitialConditions()

y0 = [    
    11.6841837913433e-006
    146.179586110510e-006
   -165.640576599269e-033
    49.2206657633235e-018
    1.96886793281630e+000
    0.00000000000000e+000
    72.4643698328235e-003
    57.1034644222131e-003
    833.330000000047e-006
    5.80788161047906e+000
    5.50957299112387e-003
    17.8069995008216e-003
    57.5511196057763e-003
    185.996962186423e-003
    601.098422372726e-003
    1.94253349031892e+000
    6.27727131660822e+000
    1.70467080150648e-003
    3.67020621924998e-003
    527.445748446510e-006
    19.5960525757519e+000
    2.68340754492802e-003
    9.05152069800287e-006
    102.898016297588e-003
    8.77887718273689e+000
    50.5899691454998e+000
    8.77893143940737e+000
    25.0516980120091e-009
    26.5664772024786e-009
    228.957777132503e-003
    2.11401179447920e-003
    215.859017441227e-003
    24.1452298012320e-003
    3.90558429771833e+000
    608.118921374976e-006
    49.2666607336592e-018
    33.9263749599363e-021
    895.172298783481e-003
    7.88598820552088e-003
    43.6758831990758e+000
    4.80386249980292e+000
    4.09726740607726e+000
    5.49127664405451e+000
    526.416986750794e-003
    19.6221268216815e+000
    93.1738386686476e-003
    208.871712346365e-003
    141.031430902806e-003
    3.40358830929442e-003
    9.16910257097024e-003
    138.622379050944e-003
    809.845163249851e-009
    303.214764631240e-003
    2.02446754516644e-006
    2.01387738880375e-003
    52.8546443259716e-003
    119.854503298794e-003
    16.6435361039754e-003
    23.1988960248175e-006
   -1.02908039208078e-030
    294.977480664267e-003
    20.5266765758850e-003
   -1.49617933184102e-030
    1.33500084547313e-003
    455.300345054823e-003
    654.655868317767e-003
    3.97281755952836e-003
    989.267059445758e-003
    1.04005942079084e+000
    7.87408357557344e-003
    1.13718125808153e+000
    1.16002248286978e-003
    26.5740701461987e-006
    1.45966754888938e+000
    3.66806301924218e-003
    20.1641662790275e-003
    44.9530763876368e+000
    284.747176815685e-003
    8.75400006902655e-003
    2.81474214497862e+000
    17.0855102266607e-003
    23.4126297422310e+000
    4.12308153621113e+000
    71.1883164945724e-003
    91.1858217724813e-003
    106.459730619493e-006
    7.06868647883650e-003
    141.164767187960e-003
    341.115813583251e-006
    4.72881786607150e+000
    400.836142286129e-003
    493.927799196287e-003
    2.81768028133236e+000
    195.172298783481e-003
    831.421451262239e-006
    43.9160341557023e-003
    14.6388321146873e-003
    63.6439743332089e-003
    38.1890807210105e-003
    230.289610921555e-006
    23.0858355133618e-003
    731.941578419702e-003
    17.1515484700064e-003
    7.71818070016391e-003
    77.1816616053815e-003
    2.30307033957720e-003
    3.86054353886034e-003
    839.234247373096e-006
    459.680807237988e-024
    310.507077373023e-024
    15.0678114729838e+000
    1.43887097580677e+000
    12.6414461947265e-003
    44.3570779715082e-003
    289.860873126897e-003
    1.20311058533789e-234
    649.472478203900e-237
    104.827701216519e-003
    52.7821002771987e-003
    55.9736200763886e-003
    1.32979378075035e-003
   -151.853692980982e-033
   -278.832802864784e-033
   -3.72646541033303e-030
   -6.82607903890756e-030
    2.11996728615045e-003
    2.24815283513637e-003
    13.0152211401583e-003
    499.042718161423e-003
    499.042718161423e-003
    499.039623208949e-003
    1.51018475028474e-009
    2.57354313443656e-003
    35.2117707698441e-003
    197.539427240867e-003
    396.411690705564e-006
    230.897429029710e-006
    2.45795446052642e-003
   -224.869399251943e-033
    63.8868081720234e-003
    4.44570883685630e-003
    32.7727366742563e-003
    2.77810405686069e-003
    284.787453793834e-003
    7.66965494517747e-003
    25.4083525325024e-006
    19.1228859545282e-006
    2.30570858367496e+000
    5.91862277926102e-003
    714.282448992008e-006
    1.82550065056143e-003
    2.66213941566112e-003
    391.224718143359e-003
   -6.88399453640929e-033
    28.9555253696596e-003
    6.34469684845153e-003
    9.31571759196573e-021
    13.7910544572400e-021
    69.7440923098138e-006
    171.328425245452e-006
    50.0000000000000e+000
    699.990000000000e+000
    2.70000000000000e+003
    0.00000000000000e+000
    4.00000000000000e+003
    24.0000000000000e-003
    0.00000000000000e+000
    500.000000000000e+000
    2.40000000000000e+000
    0.00000000000000e+000
    0.00000000000000e+000
    150.000000000000e+000
    70.0000000000000e+000
    303.214764631240e-003
    199.314514449721e-003
    8.77893146597385e+000
    228.957802184201e-003
    978.062128069022e-003
   -52.8951446680910e+000
    69.3922677554963e-003
    163.499688329031e-003
    169.790367679848e-003
    697.312315211776e-003
    15.2688255985504e-003
    300.418078938017e-003
    16.0186471681803e-003
    125.948365545750e-003
    21.9894650098464e-003
    0.00000000000000e+000
    50.4008846014388e-006
    978.062128069022e-003
    21.1112104668308e-003
    809.195201306425e-006
    16.8623711090202e-006
];


Loading data, please wait...