Cell signaling/ion channel variability effects on neuronal response (Anderson, Makadia, et al. 2015)

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Accession:185300
" ... We evaluated the impact of molecular variability in the expression of cell signaling components and ion channels on electrophysiological excitability and neuromodulation. We employed a computational approach that integrated neuropeptide receptor-mediated signaling with electrophysiology. We simulated a population of neurons in which expression levels of a neuropeptide receptor and multiple ion channels were simultaneously varied within a physiological range. We analyzed the effects of variation on the electrophysiological response to a neuropeptide stimulus. ..."
Reference:
1 . Anderson WD, Makadia HK, Vadigepalli R (2016) Molecular variability elicits a tunable switch with discrete neuromodulatory response phenotypes. J Comput Neurosci 40:65-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor; Molecular Network;
Brain Region(s)/Organism:
Cell Type(s): Brainstem neuron;
Channel(s): I L high threshold; I A; I K,Ca; I Sodium; I Potassium; Na/Ca exchanger; I_Na,Ca; I_KD;
Gap Junctions:
Receptor(s): AT1R;
Gene(s):
Transmitter(s): Angiotensin;
Simulation Environment: MATLAB;
Model Concept(s): Activity Patterns; Action Potentials; Signaling pathways; Spike Frequency Adaptation; Parameter sensitivity; Depolarization block; G-protein coupled; Conductance distributions; Bifurcation; Synaptic noise; Neuromodulation;
Implementer(s): Makadia, Hirenkumar K [hiren.makadia at gmail.com]; Anderson, Warren D [warren.anderson at jefferson.edu]; Vadigepalli, Rajanikanth [Rajanikanth.Vadigepalli at jefferson.edu];
Search NeuronDB for information about:  AT1R; I L high threshold; I A; I K,Ca; I Sodium; I Potassium; Na/Ca exchanger; I_Na,Ca; I_KD; Angiotensin;
function modelparameters=LoadParameters(cond)

%% Signaling parameters

p_1_1 = 	1;
p_1_2 = 	2;
p_2_1 = 	1;
p_2_2 = 	1.75;
p_3_1 = 	1;
p_3_2 = 	0.5;
p_4_1 = 	1;
p_4_2 = 	0.06;
p_5_1 = 	1;
p_5_2 = 	0.003;
p_6_1 = 	0.014999625;
p_6_2 = 	0.006;
	
p_7_1 = 	0.41482;
p_7_2 = 	45;
p_8_1 = 	80.357;
p_8_2 = 	180;
	
p_9_1 = 	0.096786;
p_9_2 = 	10.5;
p_10_1 = 	18.75;
p_10_2 = 	42.001;
	
p_11_1 = 	6;
p_12_1 = 	0.01;
p_13_1 = 	0.0001;
	
p_14_1 = 	0.0013;
p_14_2 = 	1;
p_15_1 = 	90.6537658442;
p_15_2 = 	2.466;
	
p_16_1 = 	60;
p_16_2 = 	0.01;
	
p_17_1 = 	3;
p_17_2 = 	1;
p_18_1 = 	3600; % 36 for high Ca baseline condition
p_18_2 = 	144;
p_19_1 = 	1;
p_19_2 = 	6;
p_20_1 = 	0.465;
p_20_2 = 	10;
p_21_1 = 	72;
p_21_2 = 	72;
p_22_1 = 	3.6;
p_22_2 = 	10;
p_23_1 = 	0.6;
p_23_2 = 	0.5;
p_24_1 = 	30;
p_24_2 = 	1;
p_25_1 = 	288;
p_26_1 = 	8;
p_27_1 = 	500;
	
p_28_1 = 	4.89E-04;
p_28_2 = 	1;
p_29_1 = 	4.89E-04;
p_29_2 = 	1;
p_30_1 = 	4.89E-04;
p_30_2 = 	1;
p_31_1 = 	4.89E-04;
p_31_2 = 	1;
p_32_1 = 	4.89E-04;
p_32_2 = 	1;
p_33_1 = 	4.89E-04;
p_33_2 = 	1;
p_34_1 = 	4.89E-04;
p_34_2 = 	1;
p_35_1 = 	4.89E-04;
p_35_2 = 	1;
p_36_1 = 	0.11059;
p_36_2 = 	1;
p_37_1 = 	25;
	
p_38_1 = 	1800;
p_38_2 = 	360;
	
p_39_1 = 	50;
p_39_2 = 	0.1;
p_40_1 = 	19.231;
p_40_2 = 	1;
p_41_1 = 	1000.2;
p_41_2 = 	0.1;
p_42_1 = 	50;
p_42_2 = 	5;
	
p_43_1 = 	0.3431978192;
p_43_2 = 	1.4;
p_44_1 = 	0.35;
	
p_45_1 = 	0.003;
p_46_1 = 	0.35;
p_47_1 = 	0.35;
	
p_48_1 = 	0.3431978192;
p_48_2 = 	1.4;
p_49_1 = 	0.3431978192;
p_49_2 = 	1.4;
p_50_1 = 	6;
p_51_1 = 	6;
	
p_52_1 = 	599995.2000384;
p_52_2 = 	2;
p_53_1 = 	924009.46185689;
p_53_2 = 	2;
p_54_1 = 	0.35;
	
p_55_1 = 	7199942.4004608;
p_55_2 = 	24;
p_56_1 = 	11088113.542283;
p_56_2 = 	24;
p_57_1 = 	0.3431978192;
p_57_2 = 	1.4;
p_58_1 = 	0.35;
	
p_59_1 = 	0.3431978192;
p_59_2 = 	1.4;
p_60_1 = 	0.5;
p_61_1 = 	0.5;
	
p_62_1 = 	25;
	
p_63_1 = 	144;
	
p_64_1 = 	0.15;
p_65_1 = 	0.0079998;
p_65_2 = 	8.6348;
p_66_1 = 	0.0006;
p_66_2 = 	0.1;
p_67_1 = 	0.003;
p_68_1 = 	2.5;
p_69_1 = 	10;
p_70_1 = 	75;
p_71_1 = 	160;
	
p_72_1 = 	1;
p_72_2 = 	1.6;
p_73_1 = 	1;
p_73_2 = 	0.2;
p_74_1 = 	75;
p_74_2 = 	25.5;
p_75_1 = 	90.6537658442;
p_75_2 = 	3.0825;
	
p_76_1 = 	0.0133;
p_77_1 = 	1.6667;
	
p_78_1 = 	25.2;
p_78_2 = 	1;
p_79_1 = 	2.52;
p_79_2 = 	1;
	
p_80_1 = 	0.6;
p_80_2 = 	1;
p_81_1 = 	0.006;
p_81_2 = 	0.0001;
	
p_82_1 = 	0.35719;
p_82_2 = 	45.72;
p_83_1 = 	0.11;
p_84_1 = 	117.33;
p_85_1 = 	39.2;
	
p_86_1 = 	35;
p_86_2 = 	0.336;
p_87_1 = 	55;
	
p_88_1 = 	1.035;
p_88_2 = 	157.32;
p_89_1 = 	2;
	
p_90_1 = 	0.00078582;
p_90_2 = 	11.43;
	
p_91_1 = 	0.00207;
p_91_2 = 	39.33;
	
p_92_1 = 	733.3216665208;
p_92_2 = 	469.32;
p_93_1 = 	52.972972973;
p_93_2 = 	156.8;
p_94_1 = 	20;
	
p_95_1 = 	1.9999600008;
p_95_2 = 	8;
p_96_1 = 	1.1;
p_97_1 = 	10.667;
	
p_98_1 = 	11.9570416105;
p_98_2 = 	220;
p_99_1 = 	4.125;
	
p_100_1 = 	4.2666;
p_100_2 = 	1.024;
p_101_1 = 	1.0311468853;
p_101_2 = 	16.5;
p_102_1 = 	4.9997500125;
p_102_2 = 	80;
p_103_1 = 	0.09;
	
p_104_1 = 	0.003;
p_105_1 = 	1;
p_105_2 = 	0.001;
p_106_1 = 	0.013;
p_107_1 = 	10.8839285714;
p_107_2 = 	12.19;%15.2375
p_108_1 = 	10.8839285714;
p_108_2 = 	12.19;
p_109_1 = 	2.7209642857;
p_109_2 = 	3.04748;
p_110_1 = 	1.8333333333;
p_110_2 = 	4.4;
p_111_1 = 	2.9629962944;
p_111_2 = 	42.6669333;
p_112_1 = 	0.0012;
	
p_113_1 = 	1;
p_113_2 = 	0.001;
p_114_1 = 	4.675;
	
p_115_1 = 	0.0060335;
p_115_2 = 	0.070136;
p_116_1 = 	0.256;
	
p_117_1 = 	31.2;
p_117_2 = 	2.496;
p_118_1 = 	0.056;
p_118_2 = 	0.624;
	
p_119_1 = 	0.05;
p_119_2 = 	1;
	
p_120_1 = 	1.5625;
p_120_2 = 	2;%2.5
p_121_1 = 	1;
p_121_2 = 	2;%2.5
p_122_1 = 	0.6666666667;
p_122_2 = 	16;%20
	
p_123_1 = 	0.5;
p_124_1 = 	0.5;
	
p_125_1 = 	4;
	
p_126_1 = 	1.5625;
p_126_2 = 	2;
p_127_1 = 	1;
p_127_2 = 	2;
	
p_128_1 = 	0.5;
p_129_1 = 	0.5;
	
p_130_1 = 	1;
p_130_2 = 	0.001;
p_131_1 = 	0.014999625;
p_131_2 = 	0.0048;
p_132_1 = 	0.5624859379;
p_132_2 = 	0.36;
p_133_1 = 	3.0475;
p_134_1 = 	3.0475;
p_135_1 = 	0.76187;
	
p_136_1 = 	0.001;
p_136_2 = 	1;
p_137_1 = 	179.8076923077;
p_137_2 = 	18.7;
	
p_138_1 = 	0.15;
p_139_1 = 	0.003;
	
p_140_1 = 	53.75;
p_140_2 = 	17.2;
p_141_1 = 	0.013;
p_142_1 = 	1;
p_142_2 = 	0.001;
p_143_1 = 	0.000335;
	
p_144_1 = 	0.001;
p_144_2 = 	1;
p_145_1 = 	0.2321;
	
p_146_1 = 	0.01355;
	
p_147_1 = 	0.26875;
p_147_2 = 	4.3;
	
p_148_1 = 	0.001;
p_148_2 = 	1;
p_149_1 = 	0.0132;
	
p_150_1 = 	1;
p_150_2 = 	45;
p_151_1 = 	1;
p_152_1 = 	1.92;
p_153_1 = 	1.75E-005;
p_154_1 = 	1;
p_154_2 = 	0.001;
p_155_1 = 	0.1746268657;
p_155_2 = 	0.936;
p_156_1 = 	0.034047619;
p_156_2 = 	0.2288;
	
p_157_1 = 	0.001;
p_157_2 = 	1;
p_158_1 = 	29.0125;
p_158_2 = 	0.9284;
	
p_159_1 = 	1;
p_159_2 = 	16;
p_160_1 = 	0.0038;
p_160_2 = 	2.376;
p_161_1 = 	1;
p_161_2 = 	0.001;
p_162_1 = 	1;
p_162_2 = 	19;
p_163_1 = 	2.7216666667;
p_163_2 = 	6.532;
p_164_1 = 	5.1;
	
p_165_1 = 	0.0012;
p_165_2 = 	1.26;
p_166_1 = 	0.0108695652;
p_166_2 = 	0.25;
	
p_167_1 = 	0.001;
p_167_2 = 	1;
p_168_1 = 	220;
p_168_2 = 	0.0528;
	
p_169_1 = 	0.0016666667;
p_169_2 = 	0.05;
	
p_170_1 = 	1923;
p_170_2 = 	10;
	
p_171_1 = 	0.00012;
p_171_2 = 	0.1;
	
p_172_1 = 	1;
p_173_1 = 	50;
	
p_174_1 = 	0.0012;
p_174_2 = 	0.1;
p_175_1 = 	1.2705;
p_176_1 = 	3.5026;
p_177_1 = 	0.6;
p_177_2 = 	0.5;
	
p_178_1 = 	1;
p_179_1 = 	0.1;
	
p_180_1 = 	0.018;
p_180_2 = 	2;
	
p_181_1 = 	2;
p_182_1 = 	0.2;
	
p_183_1 = 	0.6250312516;
p_183_2 = 	12.5;
	
p_184_1 = 	1.6667;
p_185_1 = 	2.5200342725;
p_185_2 = 	50;
	
p_186_1 = 	160.003200064;
p_186_2 = 	800;
	
p_187_1 = 	75;
p_187_2 = 	375;
	
p_188_1 = 	0.234;
p_189_1 = 	0.0572;
	
p_190_1 = 	0.0027;
p_190_2 = 	2.5;
p_191_1 = 	0.6165;
p_192_1 = 	1.633;
	
p_193_1 = 	3.00E-004;
	
p_194_1 = 	1923;
p_194_2 = 	10;

p_195_1 = 25;

p_196_1 = 586.65;

p_197_1 = 196;

p_198_1 = 15.2375;

p_199_1 = 15.2375;

p_200_1 = 3.80935;

p_201_1 = 53.3339333;

p_202_1 = 1.17;

p_203_1 = 0.286;

p_204_1 = 8.165;

p_205_1 = 10;

p_206_1 = 20.625;

p_207_1 = 275;

p_208_1 = 100;

p_209_1 = 5.5;

p_210_1 = 0.45;

p_211_1 = 23.375;

p_212_1 = 1.1605;

p_213_1 = 0.066;

p_214_1 = 0.2;

p_215_1 = 0.04;

p_216_1 = 20.4;

p_217_1 = 1.75;
p_218_1 = 1.75;
p_219_1 = 1.75;
p_220_1 = 1.75;
p_221_1 = 1.75;

p_222_1 = 2.5;
p_223_1 = 30;

p_224_1 = 2.5;
p_225_1 = 2.5;
p_226_1 = 2.5;
p_227_1 = 2.5;
p_228_1 = 2.5;

p_229_1 = 30;
p_230_1 = 0.006;
p_231_1 = 20;


g.na = 3*cond(2);% Na, g,max
g.kdr = 0.9*cond(3);% Kdr, g,max
g.ka = 0.15*cond(4);% Ka, g,max
g.kahp = 0.15*cond(5); % Kahp, g,max
g.cal = 0.0015*cond(6); % CaL, g,max
g.leak = 0.01; % gleak, g,max

%phosMK1.max = 1.35;
%phosPKC1.max = 0.5200;

phosMK1.k_p = 1;  % 0 for CaMKII blocking condition
phosPKC1.k_p = 10; % 0 for PKC blocking condition
vmax = 1.2e-1;

%% initializing all params
modelparameters = [
p_1_1
p_1_2
p_2_1
p_2_2
p_3_1
p_3_2
p_4_1
p_4_2
p_5_1
p_5_2
p_6_1
p_6_2
p_7_1
p_7_2
p_8_1
p_8_2
p_9_1
p_9_2
p_10_1
p_10_2
p_11_1
p_12_1
p_13_1
p_14_1
p_14_2
p_15_1
p_15_2
p_16_1
p_16_2
p_17_1
p_17_2
p_18_1
p_18_2
p_19_1
p_19_2
p_20_1
p_20_2
p_21_1
p_21_2
p_22_1
p_22_2
p_23_1
p_23_2
p_24_1
p_24_2
p_25_1
p_26_1
p_27_1
p_28_1
p_28_2
p_29_1
p_29_2
p_30_1
p_30_2
p_31_1
p_31_2
p_32_1
p_32_2
p_33_1
p_33_2
p_34_1
p_34_2
p_35_1
p_35_2
p_36_1
p_36_2
p_37_1
p_38_1
p_38_2
p_39_1
p_39_2
p_40_1
p_40_2
p_41_1
p_41_2
p_42_1
p_42_2
p_43_1
p_43_2
p_44_1
p_45_1
p_46_1
p_47_1
p_48_1
p_48_2
p_49_1
p_49_2
p_50_1
p_51_1
p_52_1
p_52_2
p_53_1
p_53_2
p_54_1
p_55_1
p_55_2
p_56_1
p_56_2
p_57_1
p_57_2
p_58_1
p_59_1
p_59_2
p_60_1
p_61_1
p_62_1
p_63_1
p_64_1
p_65_1
p_65_2
p_66_1
p_66_2
p_67_1
p_68_1
p_69_1
p_70_1
p_71_1
p_72_1
p_72_2
p_73_1
p_73_2
p_74_1
p_74_2
p_75_1
p_75_2
p_76_1
p_77_1
p_78_1
p_78_2
p_79_1
p_79_2
p_80_1
p_80_2
p_81_1
p_81_2
p_82_1
p_82_2
p_83_1
p_84_1
p_85_1
p_86_1
p_86_2
p_87_1
p_88_1
p_88_2
p_89_1
p_90_1
p_90_2
p_91_1
p_91_2
p_92_1
p_92_2
p_93_1
p_93_2
p_94_1
p_95_1
p_95_2
p_96_1
p_97_1
p_98_1
p_98_2
p_99_1
p_100_1
p_100_2
p_101_1
p_101_2
p_102_1
p_102_2
p_103_1
p_104_1
p_105_1
p_105_2
p_106_1
p_107_1
p_107_2
p_108_1
p_108_2
p_109_1
p_109_2
p_110_1
p_110_2
p_111_1
p_111_2
p_112_1
p_113_1
p_113_2
p_114_1
p_115_1
p_115_2
p_116_1
p_117_1
p_117_2
p_118_1
p_118_2
p_119_1
p_119_2
p_120_1
p_120_2
p_121_1
p_121_2
p_122_1
p_122_2
p_123_1
p_124_1
p_125_1
p_126_1
p_126_2
p_127_1
p_127_2
p_128_1
p_129_1
p_130_1
p_130_2
p_131_1
p_131_2
p_132_1
p_132_2
p_133_1
p_134_1
p_135_1
p_136_1
p_136_2
p_137_1
p_137_2
p_138_1
p_139_1
p_140_1
p_140_2
p_141_1
p_142_1
p_142_2
p_143_1
p_144_1
p_144_2
p_145_1
p_146_1
p_147_1
p_147_2
p_148_1
p_148_2
p_149_1
p_150_1
p_150_2
p_151_1
p_152_1
p_153_1
p_154_1
p_154_2
p_155_1
p_155_2
p_156_1
p_156_2
p_157_1
p_157_2
p_158_1
p_158_2
p_159_1
p_159_2
p_160_1
p_160_2
p_161_1
p_161_2
p_162_1
p_162_2
p_163_1
p_163_2
p_164_1
p_165_1
p_165_2
p_166_1
p_166_2
p_167_1
p_167_2
p_168_1
p_168_2
p_169_1
p_169_2
p_170_1
p_170_2
p_171_1
p_171_2
p_172_1
p_173_1
p_174_1
p_174_2
p_175_1
p_176_1
p_177_1
p_177_2
p_178_1
p_179_1
p_180_1
p_180_2
p_181_1
p_182_1
p_183_1
p_183_2
p_184_1
p_185_1
p_185_2
p_186_1
p_186_2
p_187_1
p_187_2
p_188_1
p_189_1
p_190_1
p_190_2
p_191_1
p_192_1
p_193_1
p_194_1
p_194_2
p_195_1
p_196_1
p_197_1
p_198_1
p_199_1
p_200_1
p_201_1
p_202_1
p_203_1
p_204_1
p_205_1
p_206_1
p_207_1
p_208_1
p_209_1
p_210_1
p_211_1
p_212_1
p_213_1
p_214_1
p_215_1
p_216_1
p_217_1
p_218_1
p_219_1
p_220_1
p_221_1
p_222_1
p_223_1
p_224_1
p_225_1
p_226_1
p_227_1
p_228_1
p_229_1
p_230_1
p_231_1
g.na
g.kdr
g.ka
g.kahp
g.cal
g.leak
phosMK1.k_p
phosPKC1.k_p
vmax
];

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