Novel Na current with slow de-inactivation (Tsutsui, Oka 2002)

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Accession:18742
The authors found a novel Na current in teleost thalamic nuclei was well described by the m^3 h Hodgkin-Huxley model. The kinetic parameters derived from their experiments (see the reference for details) revealed that the h gate had a large time constant (~100ms at -80 to -50mV). This explains the thalamic neurons long refractory period and the gradual recovery of AP amplitude as the inter spike interval grows.
Reference:
1 . Tsutsui H, Oka Y (2002) Slow removal of Na(+) channel inactivation underlies the temporal filtering property in the teleost thalamic neurons. J Physiol 539:743-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Teleost thalamic neuron;
Channel(s): I Na,t; I K; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Axonal Action Potentials; Action Potentials;
Implementer(s): Tsutsui, H ;
Search NeuronDB for information about:  I Na,t; I K; I Sodium; I Potassium;
This model is associated with the paper:

 Tsutsui H, Oka Y.
 Slow removal of Na(+) channel inactivation underlies the temporal filtering
 property in the teleost thalamic neurons.
 J Physiol 2002 Mar 15;539(Pt 3):743-53.

The authors found a novel Na current in teleost thalamic nuclei was well 
described by the m^3 h Hodgkin-Huxley model. The kinetic parameters derived 
from their experiments (see the reference for details) revealed that the 
h gate had a large time constant (~100ms at -80 to -50mV). This explains the 
thalamic neurons long refractory period and the gradual recovery of AP 
amplitude as the inter spike interval grows. 

To run it is easiest to autolaunch and select the figure 6A,6B, or 7A.

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extracting, and compiling the mod file with mknrndll, or nrnivmodl
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(typing on the command line, draggin and dropping or double clicking)

bug: that repetitions of fig 7A produces an error has been noted.

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