Fast AMPA receptor signaling (Geiger et al 1997)

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Accession:19022
Glutamatergic transmission at a principal neuron-interneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis and modeling. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.
Reference:
1 . Geiger JR, Lubke J, Roth A, Frotscher M, Jonas P (1997) Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron 18:1009-23 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Influence of Dendritic Geometry; Detailed Neuronal Models;
Implementer(s): Roth, Arnd ;
Search NeuronDB for information about:  AMPA; Glutamate;
These files are for the modeling associated with the paper:

Geiger JR, Lubke J, Roth A, Frotscher M, Jonas P.
Submillisecond AMPA receptor-mediated signaling at a principal 
neuron-interneuron synapse.
Neuron 1997 Jun;18(6):1009-23

Abstract:
Glutamatergic transmission at a principal neuron-interneuron synapse 
was investigated by dual whole-cell patch-clamp recording in rat 
hippocampal slices combined with morphological analysis. Evoked EPSPs 
with rapid time course (half duration = 4 ms; 34 degrees C) were 
generated at multiple synaptic contacts established on the interneuron 
dendrites close to the soma. The underlying postsynaptic conductance 
change showed a submillisecond rise and decay, due to the precise timing
of glutamate release and the rapid deactivation of the postsynaptic AMPA 
receptors. Simulations based on a compartmental model of the interneuron 
indicated that the rapid postsynaptic conductance change determines the 
shape and the somatodendritic integration of EPSPs, thus enabling 
interneurons to detect synchronous principal neuron activity.


For Auto-launch...

One can create figures similar to fig8b and fig 8c from the paper by hand once
the program has started.  Pressing the "Estimate of fig 8d" button leads to
the generation of a figure similar to the one in the paper.  See the fig8d.hoc
file for modifications for higher resolution.
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for manual running...
After the mod file is compiled to make the syn2 mechanism available
currentclamp.hoc can be run with the procedure suitable for your platform.

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