Dorsal root ganglion (primary somatosensory) neurons (Rho & Prescott 2012)

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Accession:190261
In this paper, we demonstrate how dorsal root ganglion (DRG) neuron excitability can become pathologically altered, as occurs in neuropathic pain. Specifically, we reproduce pathological changes in spiking pattern (from transient to repetitive spiking) and the development of membrane potential oscillations and bursting.
Reference:
1 . Rho YA, Prescott SA (2012) Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory. PLoS Comput Biol 8:e1002524 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s): Abstract Morris-Lecar neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Action Potential Initiation; Bifurcation; Nociception;
Implementer(s): Prescott, Steven [steve.prescott at sickkids.ca]];
This is the readme for the models associated with the paper:

Rho YA, Prescott SA (2012) Identification of molecular pathologies
sufficient to cause neuropathic excitability in primary somatosensory
afferents using dynamical systems theory. PLoS Comput Biol 8:e1002524

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