Synaptic transmission at the calyx of Held (Graham et al 2001)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:19747
This model allows the user to investigate faciliation and depression in a complex Monte Carlo model of the calyx of Held, a giant synapse in the mammalian auditory system (Graham et al, 2001)
Reference:
1 . Graham BP, Wong AYC, Forsythe ID (2001) A computational model of synaptic transmission at the calyx of Held Neurocomputing 38:37-42
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): Glutamate;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Facilitation; Depression;
Implementer(s): Graham, Bruce [B.Graham at cs.stir.ac.uk];
Search NeuronDB for information about:  Glutamate; Glutamate; 
A Computational Model of Synaptic Transmission at the Calyx of Held
-------------------------------------------------------------------

This model allows the user to investigate faciliation and depression
in a complex Monte Carlo model of the calyx of Held, a giant synapse
in the mammalian auditory system.  It can be used to replicate the
results presented in the paper:

Bruce P. Graham, Adrian Y.C. Wong and Ian D. Forsythe, A computational
model of synaptic transmission at the calyx of Held, Neurcomputing
38-40: 37-42, 2001

The user is able to specify a presynaptic stimulation frequency and
duration.  The output is the postsynaptic current or voltage.

Main HOC file: run_epsc.hoc
---------------------------
Trains of EPSCs are produced that exhibit both facilitation and depression
(paper fig. 2). The relative contributions of these to the response can be
altered by changing the release probability (fig. 3).

Main HOC file: run_epsp.hoc
---------------------------
Same simulation as with "run_epsc.hoc", but fast sodium and potassium
channels are added to the soma to produce a spiking response.  Output
is now the soma voltage trace.

Graham BP, Wong AYC, Forsythe ID (2001) A computational model of synaptic transmission at the calyx of Held Neurocomputing 38:37-42

References and models cited by this paper

References and models that cite this paper

Barnes-Davies M, Forsythe ID (1995) Pre- and postsynaptic glutamate receptors at a giant excitatory synapse in rat auditory brainstem slices. J Physiol 488 ( Pt 2):387-406 [PubMed]

Bernander O, Koch C, Douglas RJ (1994) Amplification and linearization of distal synaptic input to cortical pyramidal cells. J Neurophysiol 72:2743-53 [Journal] [PubMed]

Bertram R, Sherman A, Stanley EF (1996) Single-domain/bound calcium hypothesis of transmitter release and facilitation. J Neurophysiol 75:1919-31 [Journal] [PubMed]

Brew HM, Forsythe ID (1995) Two voltage-dependent K+ conductances with complementary functions in postsynaptic integration at a central auditory synapse. J Neurosci 15:8011-22 [PubMed]

Forsythe ID, Barnes-davies M, Brew HM (1995) Brew, Excitatory Amino Acids And Synaptic Transmission

Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]

Raman IM, Trussell LO (1992) The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus. Neuron 9:173-86 [PubMed]

Trussell LO (1997) Cellular mechanisms for preservation of timing in central auditory pathways. Curr Opin Neurobiol 7:487-92 [PubMed]

von Gersdorff H, Schneggenburger R, Weis S, Neher E (1997) Presynaptic depression at a calyx synapse: the small contribution of metabotropic glutamate receptors. J Neurosci 17:8137-46 [PubMed]

Wang LY, Kaczmarek LK (1998) High-frequency firing helps replenish the readily releasable pool of synaptic vesicles. Nature 394:384-8 [PubMed]

Weis S, Schneggenburger R, Neher E (1999) Properties of a model of Ca(++)-dependent vesicle pool dynamics and short term synaptic depression Biophys J 77:2418-29 [PubMed]

Worden MK, Bykhovskaia M, Hackett JT (1997) Facilitation at the lobster neuromuscular junction: a stimulus-dependent mobilization model. J Neurophysiol 78:417-28 [Journal] [PubMed]

Wu SH, Kelly JB (1993) Response of neurons in the lateral superior olive and medial nucleus of the trapezoid body to repetitive stimulation: intracellular and extracellular recordings from mouse brain slice. Hear Res 68:189-201 [PubMed]

Carnevale NT, Morse TM (1996-2009) Research reports that have used NEURON Web published citations at the NEURON website [Journal]

Hines ML, Carnevale NT (2003) Personal Communication of NEURON bibliography

Rudnicki M, Hemmert W (2017) High entrainment constrains synaptic depression levels of an in vivo globular bushy cell model Frontiers in Computational Neuroscience 11:16 [Journal]

  • High entrainment constrains synaptic depression in a globular bushy cell (Rudnicki & Hemmert 2017) [Model]

Spirou GA, Rager J, Manis PB (2005) Convergence of auditory-nerve fiber projections onto globular bushy cells. Neuroscience 136:843-63 [PubMed]

Wong AY, Graham BP, Billups B, Forsythe ID (2003) Distinguishing between presynaptic and postsynaptic mechanisms of short-term depression during action potential trains. J Neurosci 23:4868-77 [PubMed]

(18 refs)