CA1 interneuron: K currents (Lien et al 2002)

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Accession:20015
NEURON mod files for slow and fast K-DR, and K-A potassium currents in inhibitory interneurones of stratum oriens-alveus of the hippocampal CA1 region.
Reference:
1 . Lien CC, Martina M, Schultz JH, Ehmke H, Jonas P (2002) Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol 538:405-19 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 interneuron oriens alveus;
Channel(s): I A; I K; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 interneuron oriens alveus; I A; I K; I Potassium;
NEURON mod files for K currents from the paper:
Lien, et al., Gating, modulation and subunit composition of 
voltage-gated K(+) channels in dendritic inhibitory 
interneurones of rat hippocampus. J Physiol. 2002 538:405-19.

Running the kinetics.hoc simulation file will show 
the activation and inactivation steady-states, the time constants, 
and a family of curves generated modeling the same protocols 
used for Figs.5A-6A-7A of the paper.

Markers show a few of the experimental values for
the time constants derived from Figs.5C-6C-7C-7D.

For both the fast and slow KDR currents an inactivation time constant of
1sec is assumed. KA recovery from inactivation is not implemented.

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui kinetics.hoc

Under Windows:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
kinetics.hoc 
will open the simulation window.

Questions on how to use this model with NEURON
should be directed to michele@pa.ibf.cnr.it

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