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CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
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In our experimental study, we combined paired patch-clamp recordings and two-photon Ca2+ imaging to quantify inhibition exerted by individual GABAergic contacts on hippocampal pyramidal cell dendrites. We observed that Ca2+ transients from back-propagating action potentials were significantly reduced during simultaneous activation of individual nearby GABAergic synapses. To simulate dendritic Ca2+ inhibition by individual GABAergic synapses, we employed a multi-compartmental CA1 pyramidal cell model with detailed morphology, voltage-gated channel distributions, and calcium dynamics, based with modifications on the model of Poirazi et al., 2003, modelDB accession # 20212.
Mullner FE, Wierenga CJ, Bonhoeffer T (2015) Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time.
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Neuron or other electrically excitable cell;
Hippocampus CA1 pyramidal cell;
Dendritic Action Potentials;
Muellner, Fiona E [fiona.muellner at gmail.com];
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Hippocampus CA1 pyramidal cell
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