BDNF morphological contributions to AP enhancement (Galati et al. 2016)


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Accession:206256
" ... We quantified BDNF’s effect on cultured cortical neuron morphological parameters and found that BDNF stimulates dendrite growth and addition of dendrites while increasing both excitatory and inhibitory presynaptic inputs in a spatially restricted manner. To gain insight into how these combined changes in neuron structure and synaptic input impact AP generation, we used the morphological parameters we gathered to generate computational models. Simulations suggest that BDNF-induced neuron morphologies generate more APs under a wide variety of conditions. ..."
Reference:
1 . Galati DF, Hiester BG, Jones KR (2016) Computer simulations support a morphological contribution to BDNF enhancement of action potential generation Front Cell Neurosci 10:209 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex dissociated cultured nerve cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON (web link to model);
Model Concept(s): Action Potentials; Active Dendrites; Development;
Implementer(s): Galati, Domenico F ;
Search NeuronDB for information about:  I Na,t; I K;
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