Facilitation by residual calcium (Stockbridge, Hines 1982)

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Accession:21984
The residual calcium hypothesis is compatible with facilitation of transmitter release from the neuromuscular junction.
Reference:
1 . Stockbridge N, Hines M (1982) A re-examination of the residual calcium theory for facilitation of transmitter release. Brain Res 250:378-80 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuromuscular Junction;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Facilitation;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
/
stockbridge1982
Readme
init.hoc
mosinit.hoc
start.ses
start.ses.fd1
start.ses.ft1
                            
load_file("nrngui.hoc")
taudt=1

func C() { // n
	return (1 - exp(-$1*taudt))/(1 - exp(-taudt))
}

func T() {
	return C($1)^4
}

func F() { return T($1) - 1 }

i=0
proc table1() {
	printf("DT/tau\tF1\tF2\tF3\tF1000\n")
	for case(&taudt, 1e-9, .5, .73, .75, 1, 1e9) {
		printf("%-5.2g  ", taudt)
		for case(&i, 1, 2, 3, 1000) {
			printf(" %-7.1f", F(i))
		}
		printf("\n")
	}
}

objref Avec, Bvec, Nvec, g
{
Nvec = new Vector(11)
Nvec.indgen(1,1)
Avec = Nvec.c
Bvec = Nvec.c
{taudt = 0.83 Avec.apply("F")}
{taudt = 0.50 Bvec.apply("F")}

load_file("start.ses")
g = Graph[0]
Avec.mark(g, Nvec.c.sub(1), "+", 10, 1)
Bvec.mark(g, Nvec.c.sub(1), "+", 10, 2)
}


table1()

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