ModelDB: Hippocampus CA1 pyramidal model with Na channel exhibiting slow inactivation (Menon et al. 2009)

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Hippocampus CA1 pyramidal model with Na channel exhibiting slow inactivation (Menon et al. 2009)

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Accession:222716

These NEURON simulations show the effect of prolonged inactivation of sodium channels on attenuation of trains of backpropagating action potentials (bAPs). The new sodium channel model is a Markov model derived using a state-mutating genetic algorithm, as described in the paper.
Reference:
1 . Menon V, Spruston N, Kath WL (2009) A state-mutating genetic algorithm to design ion-channel models. Proc Natl Acad Sci U S A 106:16829-34 [PubMed]

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	Hippocampus CA1 pyramidal GLU cell;
Channel(s):	I A; I K; I Sodium; I Na, slow inactivation;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	NEURON;
Model Concept(s):	Action Potentials; Ion Channel Kinetics; Markov-type model;
Implementer(s):	Menon, Vilas [vilasmenon2008 at u dot northwestern dot edu];