High entrainment constrains synaptic depression in a globular bushy cell (Rudnicki & Hemmert 2017)


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Accession:225904
" ... Here we show how different levels of synaptic depression shape firing properties of GBCs in in vivo-like conditions using computer simulations. We analyzed how an interplay of synaptic depression (0 % to 70 %) and the number of auditory nerve fiber inputs (10 to 70) contributes to the variability of the experimental data from previous studies. ... Overall, this study helps to understand how synaptic properties shape temporal processing in the auditory system. It also integrates, compares, and reconciles results of various experimental studies."
Reference:
1 . Rudnicki M, Hemmert W (2017) High entrainment constrains synaptic depression levels of an in vivo globular bushy cell model Frontiers in Computational Neuroscience 11:16
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Auditory brainstem;
Cell Type(s): Cochlear nucleus bushy cell; Auditory nerve;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: Brian (web link to method); NEURON (web link to model); Python (web link to model);
Model Concept(s): Depression; Short-term Synaptic Plasticity; Spike Frequency Adaptation;
Implementer(s): Rudnicki, Marek [marek.rudnicki at tum.de];
Search NeuronDB for information about:  Cochlear nucleus bushy cell;
(located via links below)

Rudnicki M, Hemmert W (2017) High entrainment constrains synaptic depression levels of an in vivo globular bushy cell model Frontiers in Computational Neuroscience 11:16

References and models cited by this paper

References and models that cite this paper

Borst JG (2010) The low synaptic release probability in vivo. Trends Neurosci 33:259-66 [PubMed]

Borst JG, Soria van Hoeve J (2012) The calyx of Held synapse: from model synapse to auditory relay. Annu Rev Physiol 74:199-224 [Journal] [PubMed]

Cao XJ, Oertel D (2010) Auditory nerve fibers excite targets through synapses that vary in convergence, strength, and short-term plasticity. J Neurophysiol 104:2308-20 [Journal] [PubMed]

Carnevale NT, Hines ML (2006) The NEURON Book

Cook DL, Schwindt PC, Grande LA, Spain WJ (2003) Synaptic depression in the localization of sound. Nature 421:66-70 [PubMed]

Di Guilmi MN, Wang T, Inchauspe CG, Forsythe ID, Ferrari MD, van den Maagdenberg AM, Borst JG, Uchitel OD (2014) Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i. J Neurosci 34:7047-58 [Journal] [PubMed]

Encke J,Hemmer W (2015) The Relative Timing of Inhibitory and Excitatory Currents Tunes the Shift of Best ITD in a Detailed Mammalian MSO Network Model. Auditory Model Workshop

Friauf E, Fischer AU, Fuhr MF (2015) Synaptic plasticity in the auditory system: a review. Cell Tissue Res 361:177-213 [Journal] [PubMed]

Graham BP, Wong AYC, Forsythe ID (2001) A computational model of synaptic transmission at the calyx of Held Neurocomputing 38:37-42 [Journal]

   Synaptic transmission at the calyx of Held (Graham et al 2001) [Model]

Hermann J, Grothe B, Klug A (2009) Modeling short-term synaptic plasticity at the calyx of Held using in vivo-like stimulation patterns. J Neurophysiol 101:20-30 [Journal] [PubMed]

Hosoi N, Sakaba T, Neher E (2007) Quantitative analysis of calcium-dependent vesicle recruitment and its functional role at the calyx of Held synapse. J Neurosci 27:14286-98 [PubMed]

Joris PX, Smith PH (2008) The volley theory and the spherical cell puzzle. Neuroscience 154:65-76 [Journal] [PubMed]

Joris PX, Smith PH, Yin TC (1994) Enhancement of neural synchronization in the anteroventral cochlear nucleus. II. Responses in the tuning curve tail. J Neurophysiol 71:1037-51 [Journal] [PubMed]

Keine C, Rübsamen R (2015) Inhibition shapes acoustic responsiveness in spherical bushy cells. J Neurosci 35:8579-92 [Journal] [PubMed]

Kopp-Scheinpflug C, Tolnai S, Malmierca MS, Rubsamen R (2008) The medial nucleus of the trapezoid body: comparative physiology. Neuroscience 154:160-70

Kuenzel T, Borst JG, van der Heijden M (2011) Factors controlling the input-output relationship of spherical bushy cells in the gerbil cochlear nucleus. J Neurosci 31:4260-73 [Journal] [PubMed]

Kuenzel T, Nerlich J, Wagner H, Rübsamen R, Milenkovic I (2015) Inhibitory properties underlying non-monotonic input-output relationship in low-frequency spherical bushy neurons of the gerbil. Front Neural Circuits 9:14 [Journal] [PubMed]

Liberman MC (1991) Central projections of auditory-nerve fibers of differing spontaneous rate. I. Anteroventral cochlear nucleus. J Comp Neurol 313:240-58 [PubMed]

Lorteije JA, Rusu SI, Kushmerick C, Borst JG (2009) Reliability and precision of the mouse calyx of Held synapse. J Neurosci 29:13770-84 [Journal] [PubMed]

Neher E, Sakaba T (2008) Multiple roles of calcium ions in the regulation of neurotransmitter release. Neuron 59:861-72 [PubMed]

Nerlich J, Kuenzel T, Keine C, Korenic A, Rübsamen R, Milenkovic I (2014) Dynamic fidelity control to the central auditory system: synergistic glycine/GABAergic inhibition in the cochlear nucleus. J Neurosci 34:11604-20 [Journal] [PubMed]

Nicol MJ, Walmsley B (2002) Ultrastructural basis of synaptic transmission between endbulbs of Held and bushy cells in the rat cochlear nucleus. J Physiol 539:713-23 [PubMed]

Oleskevich S, Clements J, Walmsley B (2000) Release probability modulates short-term plasticity at a rat giant terminal. J Physiol 524 Pt 2:513-23 [PubMed]

Osen KK (1969) Cytoarchitecture of the cochlear nuclei in the cat. J Comp Neurol 136:453-84 [PubMed]

Recio A, Rhode WS (2000) Representation of vowel stimuli in the ventral cochlear nucleus of the chinchilla. Hear Res 146:167-84 [PubMed]

Rhode WS (2008) Response patterns to sound associated with labeled globular/bushy cells in cat. Neuroscience 154:87-98 [Journal] [PubMed]

Rhode WS, Greenberg S (1994) Encoding of amplitude modulation in the cochlear nucleus of the cat. J Neurophysiol 71:1797-825 [PubMed]

Rhode WS, Oertel D, Smith PH (1983) Physiological response properties of cells labeled intracellularly with horseradish peroxidase in cat ventral cochlear nucleus. J Comp Neurol 213:448-63 [PubMed]

Rothman JS, Manis PB (2003a) Differential expression of three distinct potassium currents in the ventral cochlear nucleus. J Neurophysiol 89:3070-82 [Journal] [PubMed]

   CN bushy, stellate neurons (Rothman, Manis 2003) [Model]

Rothman JS, Manis PB (2003b) Kinetic analyses of three distinct potassium conductances in ventral cochlear nucleus neurons. J Neurophysiol 89:3083-96 [Journal] [PubMed]

   CN bushy, stellate neurons (Rothman, Manis 2003) [Model]

Rothman JS, Manis PB (2003c) The roles potassium currents play in regulating the electrical activity of ventral cochlear nucleus neurons. J Neurophysiol 89:3097-113 [Journal] [PubMed]

   CN bushy, stellate neurons (Rothman, Manis 2003) (Brian) [Model]
   CN bushy, stellate neurons (Rothman, Manis 2003) [Model]

Rothman JS, Young ED, Manis PB (1993) Convergence of auditory nerve fibers onto bushy cells in the ventral cochlear nucleus: implications of a computational model. J Neurophysiol 70:2562-83 [Journal] [PubMed]

Rudnicki M,Hemmert W (2014) Cochlea: inner ear models in Python. https://github.com/mrkrd/

Rudnicki M,Hemmert W (2016) Cochlear Nucleus neurons in NEURON and Brian. https://github.com/mrkrd/cochlear_nucleus

Smith PH, Joris PX, Yin TC (1993) Projections of physiologically characterized spherical bushy cell axons from the cochlear nucleus of the cat: evidence for delay lines to the medial superior olive. J Comp Neurol 331:245-60 [PubMed]

Spirou GA, Brownell WE, Zidanic M (1990) Recordings from cat trapezoid body and HRP labeling of globular bushy cell axons. J Neurophysiol 63:1169-90 [Journal] [PubMed]

Spirou GA, Rager J, Manis PB (2005) Convergence of auditory-nerve fiber projections onto globular bushy cells. Neuroscience 136:843-63 [PubMed]

Taschenberger H, Woehler A, Neher E (2016) Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength. Proc Natl Acad Sci U S A 113:E4548-57 [Journal] [PubMed]

Tsodyks MV, Markram H (1997) The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability. Proc Natl Acad Sci U S A 94:719-23 [PubMed]

Wang T, de Kok L, Willemsen R, Elgersma Y, Borst JG (2015) In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome. Front Cell Neurosci 9:234 [Journal] [PubMed]

Wang T, Rusu SI, Hruskova B, Turecek R, Borst JG (2013) Modulation of synaptic depression of the calyx of Held synapse by GABA(B) receptors and spontaneous activity. J Physiol 591:4877-94 [Journal] [PubMed]

Wang Y, Manis PB (2008) Short-term synaptic depression and recovery at the mature mammalian endbulb of Held synapse in mice. J Neurophysiol 100:1255-64 [Journal] [PubMed]

Xu-Friedman MA, Regehr WG (2005) Dynamic-clamp analysis of the effects of convergence on spike timing. I. Many synaptic inputs. J Neurophysiol 94:2512-25 [Journal] [PubMed]

Yang H, Xu-Friedman MA (2008) Relative roles of different mechanisms of depression at the mouse endbulb of Held. J Neurophysiol 99:2510-21 [Journal] [PubMed]

Yang H, Xu-Friedman MA (2009) Impact of synaptic depression on spike timing at the endbulb of Held. J Neurophysiol 102:1699-710 [Journal] [PubMed]

Yang H, Xu-Friedman MA (2015) Skipped-stimulus approach reveals that short-term plasticity dominates synaptic strength during ongoing activity. J Neurosci 35:8297-307 [Journal] [PubMed]

Young ED, Sachs MB (2008) Auditory nerve inputs to cochlear nucleus neurons studied with cross-correlation. Neuroscience 154:127-38 [Journal] [PubMed]

Zilany MS, Bruce IC, Carney LH (2014) Updated parameters and expanded simulation options for a model of the auditory periphery. J Acoust Soc Am 135:283-6 [Journal] [PubMed]

   Cochlea: inner ear models in Python (Zilany et al 2009, 2014; Holmberg M 2007) [Model]

Zilany MS, Bruce IC, Nelson PC, Carney LH (2009) A phenomenological model of the synapse between the inner hair cell and auditory nerve: long-term adaptation with power-law dynamics. J Acoust Soc Am 126:2390-412 [Journal] [PubMed]

   Cochlea: inner ear models in Python (Zilany et al 2009, 2014; Holmberg M 2007) [Model]
   Long-term adaptation with power-law dynamics (Zilany et al. 2009) [Model]

(49 refs)