VTA dopamine neuron (Tarfa, Evans, and Khaliq 2017)

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Accession:226254
In our model of a midbrain VTA dopamine neuron, we show that the decay kinetics of the A-type potassium current can control the timing of rebound action potentials.
Reference:
1 . Tarfa RA, Evans RC, Khaliq ZM (2017) Enhanced sensitivity to hyperpolarizing inhibition in mesoaccumbal relative to nigrostriatal dopamine neuron subpopulations. J Neurosci [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Ventral tegmental area dopamine neuron;
Channel(s): I A; I A, slow; I K,Ca; I Calcium; I Na, leak; I Na,t; I T low threshold; I L high threshold; I h; I K; I N; I R;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: GENESIS;
Model Concept(s): Ion Channel Kinetics; Action Potentials; Activity Patterns;
Implementer(s): Evans, Rebekah [Rebekah.Evans at nih.gov];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca; I Calcium; I A, slow; I R; I Na, leak; Gaba;
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VTA2.14clean
DAcell
DAstims
output
README
Graphics.g
RunCell.g
                            
This is a model of a midbrain dopamine neuron presented in the paper

Tarfa RA, Evans RC, Khaliq ZM (2017) Enhanced sensitivity to
hyperpolarizing inhibition in mesoaccumbal relative to nigrostriatal
dopamine neuron subpopulations. J Neurosci

This model was contributed by Dr R Evans and requires the GENESIS
simulator which is freely available from:
http://genesis-sim.org/

To run simulations as seen in figure 11, run "RunCell.g" from the
genesis simulation environment.

Default settings are:

An A-type potassium channel with a slow inactivation time constant
(200ms), which can be changed in the file
DACell/channels/Kaf.g

The other default settings which are altered in the paper are the Ih
gmax = 0.5 S/m^2 and the T-type Ca channel permeability = 1e-7 cm/s
(both in globals.g).

Together these default settings make a 'VTA-like' midbrain dopamine neuron. 

When changing inactivation time constant for current clamp
simulations, the Gmax (in DAcell/globals.g) for the Kaf channel was
adjusted to make the peak currents similar in a single compartment
voltage clamp simulation.

The tau and gmax correspondance is:
tau=200ms, gmax= 24.5 S/m^s
tau=150ms, gmax= 24.5 S/m^s
tau=100ms, gmax= 25 S/m^s
tau=50ms, gmax= 27.5 S/m^s
tau=25ms, gmax= 32 S/m^s

Again, the tau is changed in the channel file (Kaf.g) and the gmax is
changed in the globals file (globals.g)

GABA stimulation simulations can be run by un-commenting
"include DAstims/GABAstim.g" in RunCell.g




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